Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Mar 10;4(3):141-142.
doi: 10.1016/j.medj.2023.02.007.

γδ T cells turn the tables on immune-evasive colon cancer

Seth B Coffelt  1 , Toshiyasu Suzuki  2
Affiliations
Free article
Comment

γδ T cells turn the tables on immune-evasive colon cancer

Seth B Coffelt et al. Med. .
Free article

Abstract

Why is checkpoint blockade immunotherapy still effective in tumors that are unrecognizable to CD8+ T cells? In a recent study published in Nature, de Vries et al.1 provide evidence that the lesser-known γδ T cell population may mediate beneficial responses to immune checkpoint blockade when cancer cells lose HLA expression.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • γδ T cells are effectors of immunotherapy in cancers with HLA class I defects.
    de Vries NL, van de Haar J, Veninga V, Chalabi M, Ijsselsteijn ME, van der Ploeg M, van den Bulk J, Ruano D, van den Berg JG, Haanen JB, Zeverijn LJ, Geurts BS, de Wit GF, Battaglia TW, Gelderblom H, Verheul HMW, Schumacher TN, Wessels LFA, Koning F, de Miranda NFCC, Voest EE. de Vries NL, et al. Nature. 2023 Jan;613(7945):743-750. doi: 10.1038/s41586-022-05593-1. Epub 2023 Jan 11. Nature. 2023. PMID: 36631610 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources