Autoantibodies targeting G protein-coupled receptors: An evolving history in autoimmunity. Report of the 4th international symposium

Otávio Cabral-Marques¹, Guido Moll², Rusan Catar³, Beate Preuß⁴, Lukas Bankamp⁴, Ann-Christin Pecher⁴, Joerg Henes⁴, Reinhild Klein⁴, A S Kamalanathan⁵, Reza Akbarzadeh⁶, Wieke van Oostveen⁷, Bettina Hohberger⁸, Matthias Endres⁹, Bryan Koolmoes⁷, Nivine Levarht⁷, Rudmer Postma¹⁰, Vincent van Duinen¹⁰, Anton Jan van Zonneveld¹⁰, Jeska de Vries-Bouwstra⁷, Cynthia Fehres⁷, Florian Tran¹¹, Fernando Yuri Nery do Vale¹², Kamilla Batista da Silva Souza¹³, Igor Salerno Filgueiras¹³, Lena F Schimke¹³, Gabriela Crispim Baiocchi¹³, Gustavo Cabral de Miranda¹³, Dennyson Leandro Mathias da Fonseca¹⁴, Paula Paccielli Freire¹³, Alexander M Hackel⁶, Hanna Grasshoff⁶, Anja Stähle⁶, Antje Müller⁶, Ralf Dechend¹⁵, Xinhua Yu¹⁶, Frank Petersen¹⁶, Franziska Sotzny¹⁷, Thomas P Sakmar¹⁸, Hans D Ochs¹⁹, Kai Schulze-Forster²⁰, Harald Heidecke²⁰, Carmen Scheibenbogen¹⁷, Yehuda Shoenfeld²¹, Gabriela Riemekasten²²

Affiliations

¹ Department of Medicine, Division of Molecular Medicine, University of São Paulo School of Medicine, São Paulo, Brazil; Laboratory of Medical Investigation 29, University of São Paulo School of Medicine, São Paulo, Brazil; Department of Pharmacy and Postgraduate Program of Health and Science, Federal University of Rio Grande do Norte, Natal, Brazil; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil; Interunit Postgraduate Program on Bioinformatics, Institute of Mathematics and Statistics (IME), University of Sao Paulo (USP), Sao Paulo, Brazil. Electronic address: otavio.cmarques@usp.br.
² Department of Nephrology and Internal Intensive Care Medicine, Charité University Hospital, Berlin, Germany; BIH Center for Regenerative Therapies (BCRT) and Berlin-Brandenburg School for Regenerative Therapies (BSRT), all Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
³ Department of Nephrology and Internal Intensive Care Medicine, Charité University Hospital, Berlin, Germany.
⁴ Department of Internal Medicine II, University of Tübingen, Tübingen, Germany.
⁵ Centre for BioSeparation Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, India.
⁶ Department of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.
⁷ Leiden University Medical Center (LUMC), Department of Rheumatology, Leiden, the Netherlands.
⁸ Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
⁹ Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt- Universität zu Berlin, Department of Neurology with Experimental Neurology, Berlin, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, Berlin, Germany; Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure Cluster of Excellence, Berlin, Germany; Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Center for Stroke Research Berlin, Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE), Partner Site Berlin, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany.
¹⁰ LUMC, Department of Internal Medicine (Nephrology), Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden, the Netherlands.
¹¹ Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
¹² Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
¹³ Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
¹⁴ Interunit Postgraduate Program on Bioinformatics, Institute of Mathematics and Statistics (IME), University of Sao Paulo (USP), Sao Paulo, Brazil.
¹⁵ Experimental and Clinical Research Center, A collaboration of Max Delbruck Center for Molecular Medicine and Charité Universitätsmedizin, and HELIOS Clinic, Department of Cardiology and Nephrology, Berlin 13125, Germany.
¹⁶ Priority Area Chronic Lung Diseases, Research Center Borstel (RCB), Member of the German Center for Lung Research (DZL), Borstel, Germany.
¹⁷ Institute for Medical Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität Zu Berlin, Berlin, Germany.
¹⁸ Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, NY, USA.
¹⁹ University of Washington School of Medicine and Seattle Children's Research Institute, Seattle, WA, USA.
²⁰ CellTrend GmbH, Luckenwalde, Germany.
²¹ Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.
²² Department of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany. Electronic address: gabriela.riemekasten@uksh.de.

PMID: 36906052
DOI: 10.1016/j.autrev.2023.103310

Review

Autoantibodies targeting G protein-coupled receptors: An evolving history in autoimmunity. Report of the 4th international symposium

Otávio Cabral-Marques et al. Autoimmun Rev. 2023 May.

. 2023 May;22(5):103310.

doi: 10.1016/j.autrev.2023.103310. Epub 2023 Mar 10.

Authors

Affiliations

¹ Department of Medicine, Division of Molecular Medicine, University of São Paulo School of Medicine, São Paulo, Brazil; Laboratory of Medical Investigation 29, University of São Paulo School of Medicine, São Paulo, Brazil; Department of Pharmacy and Postgraduate Program of Health and Science, Federal University of Rio Grande do Norte, Natal, Brazil; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil; Interunit Postgraduate Program on Bioinformatics, Institute of Mathematics and Statistics (IME), University of Sao Paulo (USP), Sao Paulo, Brazil. Electronic address: otavio.cmarques@usp.br.
² Department of Nephrology and Internal Intensive Care Medicine, Charité University Hospital, Berlin, Germany; BIH Center for Regenerative Therapies (BCRT) and Berlin-Brandenburg School for Regenerative Therapies (BSRT), all Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
³ Department of Nephrology and Internal Intensive Care Medicine, Charité University Hospital, Berlin, Germany.
⁴ Department of Internal Medicine II, University of Tübingen, Tübingen, Germany.
⁵ Centre for BioSeparation Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, India.
⁶ Department of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.
⁷ Leiden University Medical Center (LUMC), Department of Rheumatology, Leiden, the Netherlands.
⁸ Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
⁹ Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt- Universität zu Berlin, Department of Neurology with Experimental Neurology, Berlin, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, Berlin, Germany; Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure Cluster of Excellence, Berlin, Germany; Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Center for Stroke Research Berlin, Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE), Partner Site Berlin, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany.
¹⁰ LUMC, Department of Internal Medicine (Nephrology), Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden, the Netherlands.
¹¹ Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
¹² Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
¹³ Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
¹⁴ Interunit Postgraduate Program on Bioinformatics, Institute of Mathematics and Statistics (IME), University of Sao Paulo (USP), Sao Paulo, Brazil.
¹⁵ Experimental and Clinical Research Center, A collaboration of Max Delbruck Center for Molecular Medicine and Charité Universitätsmedizin, and HELIOS Clinic, Department of Cardiology and Nephrology, Berlin 13125, Germany.
¹⁶ Priority Area Chronic Lung Diseases, Research Center Borstel (RCB), Member of the German Center for Lung Research (DZL), Borstel, Germany.
¹⁷ Institute for Medical Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität Zu Berlin, Berlin, Germany.
¹⁸ Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, NY, USA.
¹⁹ University of Washington School of Medicine and Seattle Children's Research Institute, Seattle, WA, USA.
²⁰ CellTrend GmbH, Luckenwalde, Germany.
²¹ Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.
²² Department of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany. Electronic address: gabriela.riemekasten@uksh.de.

PMID: 36906052
DOI: 10.1016/j.autrev.2023.103310

Abstract

G protein-coupled receptors (GPCR) are involved in various physiological and pathophysiological processes. Functional autoantibodies targeting GPCRs have been associated with multiple disease manifestations in this context. Here we summarize and discuss the relevant findings and concepts presented in the biennial International Meeting on autoantibodies targeting GPCRs (the 4th Symposium), held in Lübeck, Germany, 15-16 September 2022. The symposium focused on the current knowledge of these autoantibodies' role in various diseases, such as cardiovascular, renal, infectious (COVID-19), and autoimmune diseases (e.g., systemic sclerosis and systemic lupus erythematosus). Beyond their association with disease phenotypes, intense research related to the mechanistic action of these autoantibodies on immune regulation and pathogenesis has been developed, underscoring the role of autoantibodies targeting GPCRs on disease outcomes and etiopathogenesis. The observation repeatedly highlighted that autoantibodies targeting GPCRs could also be present in healthy individuals, suggesting that anti-GPCR autoantibodies play a physiologic role in modeling the course of diseases. Since numerous therapies targeting GPCRs have been developed, including small molecules and monoclonal antibodies designed for treating cancer, infections, metabolic disorders, or inflammatory conditions, anti-GPCR autoantibodies themselves can serve as therapeutic targets to reduce patients' morbidity and mortality, representing a new area for the development of novel therapeutic interventions.

Keywords: Anti-GPCR autoantibodies; Autoimmune diseases; COVID-19; Post-COVID; Rheumatic diseases.

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Autoantibodies targeting G protein-coupled receptors: An evolving history in autoimmunity. Report of the 4th international symposium

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Autoantibodies targeting G protein-coupled receptors: An evolving history in autoimmunity. Report of the 4th international symposium

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