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. 2023 Sep;143(9):1813-1816.e2.
doi: 10.1016/j.jid.2023.01.037. Epub 2023 Mar 9.

A Cross-Trait Genetic Correlation Study Identified Eight Diseases and Traits Associated with Psoriasis

Kotaro Ogawa  1 , Lam C Tsoi  2 , Hiroaki Tanaka  3 , Masahiro Kanai  4 , Philip E Stuart  5 , Rajan P Nair  5 , Yoshiya Tanaka  6 , Hideki Mochizuki  7 , James T Elder  8 , Yukinori Okada  9
Affiliations

A Cross-Trait Genetic Correlation Study Identified Eight Diseases and Traits Associated with Psoriasis

Kotaro Ogawa et al. J Invest Dermatol. 2023 Sep.
No abstract available

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Conflict of interest statement

Conflict of Interest Statement

The authors declare no competing interests.

Figures

Figure 1.
Figure 1.. A cluster plot of the genetically correlated traits and diseases.
Each circle represents a trait, and each edge represents a significant genetic correlation (FDR < 0.05). Pairwise genetic correlations (n = 253) were estimated via bivariate LD score regression, and their P values were corrected via the Benjamini-Hochberg method for multiple testing of all 253 correlations. Positive genetic correlations are shown in blue, and negative correlations are shown in red in the figure. We used ldsc-network-plot (https://github.com/mkanai/ldsc-network-plot) for drawing this figure.
Figure 2.
Figure 2.. Cell-type-specificity network across the 21 human complex traits and psoriasis in the 220 cell-type-specific annotations.
Highly significant heritability enrichments connect cell types to phenotypes. Each circle represents a trait, and each square represents a cell type. The significance of heritability enrichment was estimated via stratified LD score regression. FDR was calculated via the Benjamini-Hochberg method (FDR < 1.0×10−5).
See this image and copyright information in PMC

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