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Review
. 2023 Apr;34(2):209-225.
doi: 10.1016/j.nec.2022.11.001. Epub 2023 Jan 31.

Laser Interstitial Thermal Therapy for Radionecrosis

Alexis Paul Romain Terrapon  1 , Marie Krüger  2 , Thomas Hundsberger  3 , Marian Christoph Neidert  1 , Oliver Bozinov  4
Affiliations
Review

Laser Interstitial Thermal Therapy for Radionecrosis

Alexis Paul Romain Terrapon et al. Neurosurg Clin N Am. 2023 Apr.

Abstract

Radiotherapy is widely used for brain tumors but can cause radiation necrosis (RN). Laser interstitial thermal therapy (LITT) is a relatively new therapeutic modality for RN and its impact on patient outcome is still not well understood. Based on a systematic literature search (n=33), the authors discuss the available evidence. Most studies found a positive safety/efficacy profile, as LITT may help to lengthen survival, prevent progression, taper steroids, and improve neurological symptoms while remaining safe. Prospective studies on this subject are needed and may result in LITT becoming an essential therapeutic option for the treatment of RN.

Keywords: Ablation; LITT; Outcome; Radiation necrosis; Radiotherapy; Recurrence; Review; Safety.

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