Neurosurgical Applications of Magnetic Hyperthermia Therapy

Daniel Rivera¹, Alexander J Schupper², Alexandros Bouras³, Maria Anastasiadou², Lawrence Kleinberg⁴, Dara L Kraitchman⁵, Anilchandra Attaluri⁶, Robert Ivkov⁷, Constantinos G Hadjipanayis⁸

Affiliations

¹ Department of Neurological Surgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; Department of Neurological Surgery, University of Pittsburgh, 200 Lothrop Street, Suite F-158, Pittsburgh, PA 15213, USA; Brain Tumor Nanotechnology Laboratory, UPMC Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA 15232, USA.
² Department of Neurological Surgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
³ Department of Neurological Surgery, University of Pittsburgh, 200 Lothrop Street, Suite F-158, Pittsburgh, PA 15213, USA; Brain Tumor Nanotechnology Laboratory, UPMC Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA 15232, USA.
⁴ Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, 1550 Orleans Street, Baltimore, MD 21231-5678, USA.
⁵ Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA.
⁶ Department of Mechanical Engineering, The Pennsylvania State University, 777 West Harrisburg Pike Middletown, PA 17057, USA.
⁷ Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, 1550 Orleans Street, Baltimore, MD 21231-5678, USA; Department of Oncology, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD 21231-5678, USA; Department of Mechanical Engineering, Johns Hopkins University, Whiting School of Engineering, 3400 North Charles Street, Baltimore, MD 21218, USA; Department of Materials Science and Engineering, Johns Hopkins University, Whiting School of Engineering, 3400 North Charles Street, Baltimore, MD 21218, USA.
⁸ Department of Neurological Surgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; Department of Neurological Surgery, University of Pittsburgh, 200 Lothrop Street, Suite F-158, Pittsburgh, PA 15213, USA; Brain Tumor Nanotechnology Laboratory, UPMC Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA 15232, USA. Electronic address: hadjipanayiscg2@upmc.edu.

PMID: 36906333
PMCID: PMC10726205
DOI: 10.1016/j.nec.2022.11.004

Review

Neurosurgical Applications of Magnetic Hyperthermia Therapy

Daniel Rivera et al. Neurosurg Clin N Am. 2023 Apr.

. 2023 Apr;34(2):269-283.

doi: 10.1016/j.nec.2022.11.004. Epub 2023 Jan 30.

Authors

Daniel Rivera¹, Alexander J Schupper², Alexandros Bouras³, Maria Anastasiadou², Lawrence Kleinberg⁴, Dara L Kraitchman⁵, Anilchandra Attaluri⁶, Robert Ivkov⁷, Constantinos G Hadjipanayis⁸

Affiliations

¹ Department of Neurological Surgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; Department of Neurological Surgery, University of Pittsburgh, 200 Lothrop Street, Suite F-158, Pittsburgh, PA 15213, USA; Brain Tumor Nanotechnology Laboratory, UPMC Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA 15232, USA.
² Department of Neurological Surgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
³ Department of Neurological Surgery, University of Pittsburgh, 200 Lothrop Street, Suite F-158, Pittsburgh, PA 15213, USA; Brain Tumor Nanotechnology Laboratory, UPMC Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA 15232, USA.
⁴ Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, 1550 Orleans Street, Baltimore, MD 21231-5678, USA.
⁵ Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA.
⁶ Department of Mechanical Engineering, The Pennsylvania State University, 777 West Harrisburg Pike Middletown, PA 17057, USA.
⁷ Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, 1550 Orleans Street, Baltimore, MD 21231-5678, USA; Department of Oncology, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD 21231-5678, USA; Department of Mechanical Engineering, Johns Hopkins University, Whiting School of Engineering, 3400 North Charles Street, Baltimore, MD 21218, USA; Department of Materials Science and Engineering, Johns Hopkins University, Whiting School of Engineering, 3400 North Charles Street, Baltimore, MD 21218, USA.
⁸ Department of Neurological Surgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; Department of Neurological Surgery, University of Pittsburgh, 200 Lothrop Street, Suite F-158, Pittsburgh, PA 15213, USA; Brain Tumor Nanotechnology Laboratory, UPMC Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA 15232, USA. Electronic address: hadjipanayiscg2@upmc.edu.

PMID: 36906333
PMCID: PMC10726205
DOI: 10.1016/j.nec.2022.11.004

Abstract

Magnetic hyperthermia therapy (MHT) is a highly localized form of hyperthermia therapy (HT) that has been effective in treating various forms of cancer. Many clinical and preclinical studies have applied MHT to treat aggressive forms of brain cancer and assessed its role as a potential adjuvant to current therapies. Initial results show that MHT has a strong antitumor effect in animal studies and a positive association with overall survival in human glioma patients. Although MHT is a promising therapy with the potential to be incorporated into the future treatment of brain cancer, significant advancement of current MHT technology is required.

Keywords: Brain neoplasms; Glioblastoma; High-grade glioma; Magnetic fluid hyperthermia; Magnetic hyperthermia therapy; Magnetic particle imaging; Thermotherapy.

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Conflict of interest statement

CONFLICT OF INTERESTS

Dr C.G. Hadjipanayis is a consultant for Stryker Corp., Synaptive Medical, and Hemerion.

Figures

**Fig. 1.**
Illustration of rodent MHT following intracranial MIONP delivery.

See this image and copyright information in PMC

References

1. Alumutairi L, Yu B, Filka M, et al. Mild magnetic nanoparticle hyperthermia enhances the susceptibility of Staphylococcus aureus biofilm to antibiotics. Int J Hyperthermia 2020;37(1):66–75. - PMC - PubMed
1. Gao X, Chen H. Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases. Front Med 2014;8(1):1–5. Epub 2014/01/10. - PubMed
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Neurosurgical Applications of Magnetic Hyperthermia Therapy

Affiliations

Neurosurgical Applications of Magnetic Hyperthermia Therapy

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical