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Review
. 2023 May;165(4):487-520.
doi: 10.1111/jnc.15807. Epub 2023 Mar 27.

Iron, ferroptosis, and ischemic stroke

Jun Guo  1 , Qing-Zhang Tuo  1 , Peng Lei  1
Affiliations
Review

Iron, ferroptosis, and ischemic stroke

Jun Guo et al. J Neurochem. 2023 May.

Abstract

Over 30 million people suffer from the consequences of ischemic stroke. The precise molecular mechanism of neuronal damage during ischemic stroke remains unclear; therefore, the effective treatment of post-ischemic stroke remains a critical challenge. Recently, iron has emerged as a crucial factor in post-reperfusion injuries, participating in cell peroxidation, excitotoxicity, and a distinctive cell death pathway, namely, ferroptosis. Since iron is tightly regulated in the brain and important for brain functions, the imbalance of its metabolism, including its overload and deficiency, has been shown to impact ischemic stroke outcomes. This review summarizes the current understanding of pathological events associated with iron in ischemic stroke and discusses relevant drug development.

Keywords: ferroptosis; iron deficiency; iron overload; ischemic stroke; lipid peroxidation.

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References

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