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Review
. 2023 Feb 17;18(4):28.
doi: 10.3892/mco.2023.2624. eCollection 2023 Apr.

Insight on common forms of cutaneous head and neck carcinoma (Review)

Doriana Cristea-Ene Iancu  1   2 , Ana Fulga  1   2 , Doina Vesa  1   2 , Constantin Stan  1   2 , Andrei Zenovia  3 , Florin Bujoreanu  4   5 , Alin Ionut Piraianu  2   6 , Mihaela Ionela Sarbu  2 , Alin Laurentiu Tatu  2   3   4   5
Affiliations
Review

Insight on common forms of cutaneous head and neck carcinoma (Review)

Doriana Cristea-Ene Iancu et al. Mol Clin Oncol. .

Abstract

To improve the outcome and quality of life for patients with head and neck carcinoma, an increasing amount of research has been performed on the particularities of this type of cancer and its treatment methods. Starting from clinical aspects, including histology and imaging features, up-to-date studies from different parts of the world have determined new data leading to a better understanding of the mechanisms behind the disease and proposed new treatment protocols. The head and neck areas are predisposed to almost all skin neoplasms, most commonly those related to ultraviolet exposure. Squamous cell carcinoma and basal cell carcinoma account for almost 90% of non-melanoma skin cancers in this region; therefore, reviewing the literature on cutaneous carcinomas of the head and neck area and sharing particular aspects of their physiopathology are beneficial for a great number of patients.

Keywords: basal cell carcinoma; head and neck skin cancer; squamous cell carcinoma.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Risk factors for the development of BCC and SCC. In order of association, the most significant risk factors linked with head and neck SCC and BCC are provided. SCC, squamous cell carcinoma; BCC, basal cell carcinoma.
Figure 2
Figure 2
Metabolism of miR-340 in head and neck squamous cell carcinoma. The downregulation of miR-340 acts as a metabolic switch by regulating GLUT1 activity and promoting cancer cell growth. miR, microRNA; GLUT, glucose transporter.
See this image and copyright information in PMC

References

    1. Zhu G, Lin JC, Kim SB, Bernier J, Agarwal JP, Vermorken JB, Thinh DHQ, Cheng HC, Yun HJ, Chitapanarux I, et al. Asian expert recommendation on management of skin and mucosal effects of radiation, with or without the addition of cetuximab or chemotherapy, in treatment of head and neck squamous cell carcinoma. BMC Cancer. 2016;16(42) doi: 10.1186/s12885-016-2073-z. - DOI - PMC - PubMed
    1. Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 2020;6(92) doi: 10.1038/s41572-020-00224-3. - DOI - PMC - PubMed
    1. Jicman Stan D, Niculet E, Lungu M, Onisor C, Rebegea L, Vesa D, Bezman L, Bujoreanu FC, Sarbu MI, Mihailov R, et al. Nasopharyngeal carcinoma: A new synthesis of literature data (review) Exp Ther Med. 2022;23(136) doi: 10.3892/etm.2021.11059. - DOI - PMC - PubMed
    1. Kang H, Kiess A, Chung CH. Emerging biomarkers in head and neck cancer in the era of genomics. Nat Rev Clin Oncol. 2015;12:11–26. doi: 10.1038/nrclinonc.2014.192. - DOI - PubMed
    1. Marur S, Forastiere AA. Head and neck squamous cell carcinoma: Update on epidemiology, diagnosis, and treatment. Mayo Clin Proc. 2016;91:386–396. doi: 10.1016/j.mayocp.2015.12.017. - DOI - PubMed