Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Feb 6;15(2):e34673.
doi: 10.7759/cureus.34673. eCollection 2023 Feb.

An Atypical Cause of Primary Amenorrhea: A Case Report of Rare Vaginal Agenesis

John P Petrykowski  1   2 , Ashley C Calise  1   2 , Riley A Doyle  1 , Brent J Hurd  2
Affiliations
Case Reports

An Atypical Cause of Primary Amenorrhea: A Case Report of Rare Vaginal Agenesis

John P Petrykowski et al. Cureus. .

Abstract

Vaginal agenesis is part of a group of anomalies, referred to as Mullerian anomalies due to their embryologic origin, in which there is a congenital absence of the vagina. We present a unique case in which a 20-year-old female presented to the Emergency Department with cyclical abdominal pain and primary amenorrhea. The original assessment showed a probable imperforate hymen; however, it was later found that she likely had vaginal agenesis. Vaginal agenesis is a rare disease, but it is prevalent enough that it should be kept at the forefront of the differential diagnosis in a woman with primary amenorrhea and recurring pain. We also highlight the importance of patient education in general, but categorically to sexual health.

Keywords: case report; imperforate hymen; mayer-rokitansky-kuster-hauser; mullerian agenesis; primary amenorrhea; vaginal agenesis.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Coronal view of abdomen and pelvis.
Figure 2
Figure 2. Coronal view of abdomen and pelvis.
Figure 3
Figure 3. Sagittal view of abdomen and pelvis.
Figure 4
Figure 4. Axial view of the abdomen.
Figure 5
Figure 5. Complete pelvic ultrasound; view of the uterus.
Figure 6
Figure 6. Complete pelvic ultrasound; view of the left adnexa.
Figure 7
Figure 7. A) Normal vaginal anatomy hemipelvis. B) Vaginal agenesis of the lower vagina with retained blood products and normal external vaginal anatomy hemipelvis. Illustration by Ashley Calise.
See this image and copyright information in PMC

References

    1. Marc R Laufer, MD MD, Robert L Barbieri, MD MD, Deborah Levine, MD MD. UpToDate. Waltham, MA: UpToDate; [ Jan; 2023 ]. 2022. Congenital anomalies of the hymen and vagina.
    1. Vaginal malformations. Evans T.N., Poland M.L., Boving R.L. American Journal of Obstetrics and Gynecology. 1981;141:910. - PubMed
    1. Hoffman BL, Schorge JO, Halvorson LM, et al. Williams Gynecology, 4e. McGraw Hill; 2020. Anatomic Disorders.
    1. Hoffman BL, Schorge JO, Halvorson LM, et al. Williams Gynecology, 4e. McGraw Hill; [ Dec; 2022 ]. 2020. Surgeries for Benign Gynecologic Disorders.
    1. An atypical presentation of vaginal agenesis. Huguelet PS, May LT, Scott SM. J Pediatr Adolesc Gynecol. 2015;28:0–6. - PubMed

Publication types

LinkOut - more resources