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Comment
. 2022 Oct;2(10):876-877.
doi: 10.1038/s43587-022-00289-7. Epub 2022 Oct 14.

Frailty-associated dysbiosis of human microbiotas in older adults in nursing homes

Julia Oh  1 , Julie Robison  2 , George A Kuchel  2
Affiliations
Comment

Frailty-associated dysbiosis of human microbiotas in older adults in nursing homes

Julia Oh et al. Nat Aging. 2022 Oct.

Abstract

Our longitudinal study comparing the skin, gut and oral microbiomes of community-dwelling older adults and nursing home residents showed striking changes known to be linked to antibiotic resistance and disease risk. Such shifts were associated with frailty, not chronological age, and were most pronounced in the skin, the primary reservoir for infection risk.

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Figures

Fig. 1 |
Fig. 1 |. The skin microbiota is a major reservoir of antibiotic resistance genes in residents of skilled nursing facilities.
a, Study design. YA, young adult; yr, years old. b, Differentially abundant antibiotic resistance genes between the skilled nursing facility-dwelling (SNFD) and community-dwelling (CD) cohorts for the oral, gut and skin microbiota, measured as log2(fold change in relative abundance); positive values represent enrichment in SNFD individuals. © 2022, Larson, P. J. et al.
See this image and copyright information in PMC

Comment on

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