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Review
. 2023 Feb 23:11:1137870.
doi: 10.3389/fcell.2023.1137870. eCollection 2023.

Non-canonical autophagy in aging and age-related diseases

Anita V Kumar  1 , Joslyn Mills  1   2
Affiliations
Review

Non-canonical autophagy in aging and age-related diseases

Anita V Kumar et al. Front Cell Dev Biol. .

Abstract

Autophagy, one of the arms of proteostasis, influences aging and age-related diseases. Recently, the discovery of additional roles of autophagy-related proteins in non-canonical degradation and secretion has revealed alternative fates of autophagic cargo. Some of these non-canonical pathways have been linked to neurodegenerative diseases and improving the understanding of this link is crucial for their potential targetability in aging and age-related diseases. This review discusses recent investigations of the involvement of non-canonical autophagy players and pathways in age-related diseases that are now beginning to be discovered. Unraveling these pathways and their relation to classical autophagy could unearth a fascinating new layer of proteostasis regulation during normal aging and in longevity.

Keywords: LANDO; LAP (LC3 associated phagocytosis); aging; neurodegenerative diseasaes; non-canonical autophagy; secretory autophagy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Overview of canonical and non-canonical autophagy and their dysfunctions in aging.
FIGURE 2
FIGURE 2
Potential link between autophagy dysfunction and inflammaging. Created with BioRender.com.
See this image and copyright information in PMC

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