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. 2023 Feb 21;8(9):8885-8893.
doi: 10.1021/acsomega.3c00362. eCollection 2023 Mar 7.

Utilizing Reusable Catalyst Phosphotungstic Acid for the Synthesis of Thioglycoside from Per- O-acetyl Saccharides with Microwave-Assisted and De- O-acetylation with Methanol

Jyun-Siao Chen  1 , Tai-Chung Lo  1 , Ya-Chi Hsieh  1 , Ching-Hsien Chen  1 , Michelle Lin  2 , Heng-Yan Lin  1 , Ming-Wei Hung  1 , Hsin-Ru Wu  3 , Shun-Yuan Luo  1
Affiliations

Utilizing Reusable Catalyst Phosphotungstic Acid for the Synthesis of Thioglycoside from Per- O-acetyl Saccharides with Microwave-Assisted and De- O-acetylation with Methanol

Jyun-Siao Chen et al. ACS Omega. .

Abstract

Traditional methods for synthesizing complex oligosaccharides currently developed are not efficient, requiring a new glycosylation methodology. Herein, using phosphotungstic acid (PTA) as a catalyst has demonstrated to be a simple possibility for carbohydrate synthesis. The methodology is engineered into a PTA-catalyzed thioglycoside preparation under microwave conditions and de-O-acetylation of carbohydrates. These easier operations and convenient protocols display a wide substrate scope. Moreover, both methods can be developed into a one-pot reaction for the efficient synthesis of carbohydrate analogues.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Scheme 1
Scheme 1. Synthesis of Thioglycoside
See this image and copyright information in PMC

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