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. 2023 Mar 8;15(1):e12395.
doi: 10.1002/dad2.12395. eCollection 2023 Jan-Mar.

The relationship between midlife dyslipidemia and lifetime incidence of dementia: A systematic review and meta-analysis of cohort studies

Jason Wee  1 , Sara Sukudom  2   3 , Saiuj Bhat  4 , Matti Marklund  5   6   7 , Niridu Jude Peiris  3 , Camilla M Hoyos  8 , Sanjay Patel  9 , Sharon L Naismith  10 , Girish Dwivedi  2 , Ashish Misra  3   9
Affiliations

The relationship between midlife dyslipidemia and lifetime incidence of dementia: A systematic review and meta-analysis of cohort studies

Jason Wee et al. Alzheimers Dement (Amst). .

Abstract

Introduction: We conducted a systematic review and meta-analysis to review the relationship between midlife dyslipidemia and lifetime incident dementia.

Methods: The databases Medline, Embase, Scopus, Web of Science, and Cochrane were searched from inception to February 20, 2022. Longitudinal studies examining the relationship between midlife lipid levels on dementia, dementia subtypes, and/or cognitive impairment were pooled using inverse-variance weighted random-effects meta-analysis.

Results: Seventeen studies (1.2 million participants) were included. Midlife hypercholesterolemia was associated with increased incidence of mild cognitive impairment (effect size [ES] = 2.01; 95% confidence interval [CI] 1.19 to 2.84; I2 = 0.0%) and all-cause dementia (ES = 1.14; 95% CI: 1.07 to 1.21; I2 = 0.0%). Each 1 mmol/L increase in low-density lipoprotein was associated with an 8% increase (ES = 1.08, 95% CI: 1.03 to 1.14; I2 = 0.3%) in incidence of all-cause dementia.

Discussion: Midlife dyslipidemia is associated with an increased risk of cognitive impairment in later life.

Keywords: aging; cholesterol; cognitive; cognitive dysfunction; dementia; dyslipidemia; midlife.

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Conflict of interest statement

Author disclosures are available in the supporting information.

Figures

FIGURE 1
FIGURE 1
Pooled association between total cholesterol and all‐cause dementia. HR = hazard ratio
FIGURE 2
FIGURE 2
Pooled association between low‐density lipoprotein levels and all‐cause dementia. HR = hazard ratio
FIGURE 3
FIGURE 3
Pooled association between total cholesterol and mild cognitive impairment. OR = odds ratio
FIGURE 4
FIGURE 4
Pooled association between total cholesterol and Alzheimer's disease. HR = hazard ratio, OR = odds ratio
See this image and copyright information in PMC

References

    1. Edition F. Diagnostic and statistical manual of mental disorders. Am Psychiatric Assoc. 2013;21:591‐643.
    1. Nichols E, Szoeke CE, Vollset SE, et al. Global, regional, and national burden of Alzheimer's disease and other dementias, 1990‐2016: a systematic analysis for the Global Burden of Disease Study. 2016 Lancet Neurol. 2019;18(1):88‐106. - PMC - PubMed
    1. Exchange GHD . GBD results tool. 2019;
    1. Rizzi L, Rosset I, Roriz‐Cruz M. Global epidemiology of dementia: Alzheimer's and vascular types. Biomed Res Int. 2014;908915. - PMC - PubMed
    1. Weller J, Budson A. Current understanding of Alzheimer's disease diagnosis and treatment. F1000Res. 2018;7(1): 1161‐1170. - PMC - PubMed