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Review
. 2023 Feb 24:14:1091223.
doi: 10.3389/fgene.2023.1091223. eCollection 2023.

Advances in early detection methods for solid tumors

Bowen Jiang  1 , Deqian Xie  1 , Shijin Wang  1 , Xiunan Li  1 , Guangzhen Wu  1
Affiliations
Review

Advances in early detection methods for solid tumors

Bowen Jiang et al. Front Genet. .

Abstract

During the last decade, non-invasive methods such as liquid biopsy have slowly replaced traditional imaging and invasive pathological methods used to diagnose and monitor cancer. Improvements in the available detection methods have enabled the early screening and diagnosis of solid tumors. In addition, advances in early detection methods have made the continuous monitoring of tumor progression using repeat sampling possible. Previously, the focus of liquid biopsy techniques included the following: 1) the isolation of circulating tumor cells, circulating tumor DNA, and extracellular tumor vesicles from solid tumor cells in the patient's blood; in addition to 2) analyzing genomic and proteomic data contained within the isolates. Recently, there has been a rapid devolvement in the techniques used to isolate and analyze molecular markers. This rapid evolvement in detection techniques improves their accuracy, especially when few samples are available. In addition, there is a tremendous expansion in the acquisition of samples and targets for testing; solid tumors can be detected from blood and other body fluids. Test objects have also expanded from samples taken directly from cancer to include indirect objects affected in cancer development. Liquid biopsy technology has limitations. Even so, this detection technique is the key to a new phase of oncogenetics. This review aims to provide an overview of the current advances in liquid biopsy marker selection, isolation, and detection methods for solid tumors. The advantages and disadvantages of liquid biopsy technology will also be explored.

Keywords: CTC; EVs; cfDNA; early detection; liquid biopsy; tumor.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Differences between liquid biopsy technique and tissue puncture biopsy.
FIGURE 2
FIGURE 2
A Timeline of Liquid biopsy.
FIGURE 3
FIGURE 3
Some common Tumor biomarkers.
See this image and copyright information in PMC

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