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Case Reports
. 2023 Feb 18;60(1):90-96.
doi: 10.29399/npa.27961. eCollection 2023.

Mild Encephalitis/Encephalopathy with a Reversible Lesion in The Splenium

Zerrin Yıldırım  1   2 , Sibel Mumcu Timer  3 , Didem Çelik  4 , Fazilet Karademir  2 , Nilüfer Kale  2
Affiliations
Case Reports

Mild Encephalitis/Encephalopathy with a Reversible Lesion in The Splenium

Zerrin Yıldırım et al. Noro Psikiyatr Ars. .

Abstract

Mild encephalitis/encephalopathy with a reversible lesion in the splenium (MERS) is a clinico-radiological syndrome with mild central nervous system symptoms and a reversible lesion in the splenium of the corpus callosum. It is mainly associated with a number of viral and bacterial infections, including Coronavirus disease 2019 (COVID-19). In this paper, we report four MERS patients. One had a mumps infection, the second had aseptic meningitis, the third had Marchiafava-Bignami disease, and the fourth had atypical pneumonia associated with COVID-19 infection.

Keywords: Abducens nerve palsy; COVID-19; Marchiafava-Bignami disease; intracranial hypertension; mild encephalitis/encephalopathy with a reversible splenial lesion; mumps; papilledema.

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Conflict of interest statement

Conflict of Interest: Conflict of Interest: The authors declared that there is no conflict of interest.

Figures

Figure 1
Figure 1
Magnetic resonance imaging (MRI) of the patients (ADC: apparent diffusion coefficient image; DWI: diffusion-weighted image).
See this image and copyright information in PMC

References

    1. Tada H, Takanashi J, Barkovich AJ, Oba H, Maeda M, Tsukahara H, et al. Clinically mild encephalitis/encephalopathy with a reversible splenial lesion. Neurology. 2004;63:1854–1858. - PubMed
    1. Garcia-Monco JC, Cortina IE, Ferreira E, Martinez A, Ruiz L, Cabrera A, et al. Reversible splenial lesion syndrome (RESLES):what's in a name?J Neuroimaging. 2011;21:e1–14. - PubMed
    1. Starkey J, Kobayashi N, Numaguchi Y, Moritani T. Cytotoxic Lesions of the Corpus Callosum That Show Restricted Diffusion:Mechanisms, Causes, and Manifestations. Radiographics. 2017;37:562–576. - PubMed
    1. Edjlali M, Le Gal A, Louvet M, Matt M, Leveque C, Diffre C, et al. Teaching NeuroImages:Cytotoxic lesions of the corpus callosum in encephalopathic patients with COVID-19. Neurology. 2020;95:1021–1022. - PubMed
    1. Forestier G, Beaurepaire de I, Bornet G, Boulouis G. Cytotoxic lesion of the corpus callosum as presenting neuroradiological manifestation of COVID-2019 infection. J Neurol. 2021;268:1595–1597. - PMC - PubMed

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