Mushroom consumption and risk of gastric cancer: a pooled analysis within the stomach cancer pooling project and a combined meta-analysis with other observational studies

Djibril M Ba¹, Paddy Ssentongo¹, Claudio Pelucchi², Eva Negri^{2

3}, Domenico Palli⁴, Monica Ferraroni², Zuo-Feng Zhang⁵, Guo-Pei Yu⁶, Shoichiro Tsugane^{7

8}, Akihisa Hidaka⁷, Gerson Shigueaki Hamada⁹, David Zaridze¹⁰, Dmitry Maximovich¹⁰, Mireia Obón-Santacana^{11

12

13}, Laura Álvarez-Álvarez¹⁴, Jesus Vioque^{11

15}, Manoli Garcia de la Hera^{11

15}, Lizbeth López-Carrillo¹⁶, Malaquias López-Cervantes¹⁷, Lina Mu¹⁸, Areti Lagiou¹⁹, Pagona Lagiou^{20

21}, Paolo Boffetta^{22

23}, Maria Constanza Camargo²⁴, Maria Paula Curado²⁵, Nuno Lunet^{26

27

28}, Carlo La Vecchia², Joshua Muscat¹

Affiliations

¹ Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
² Department of Clinical Sciences and Community Health, University of Milan, Milan.
³ Pegaso Online University, Naples.
⁴ Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy.
⁵ Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, California, USA.
⁶ Medical Informatics Center, Peking University, Peking, China.
⁷ Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center.
⁸ National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.
⁹ Nikkei Disease Prevention Center, São Paulo, Brazil.
¹⁰ Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia.
¹¹ Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid.
¹² Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat.
¹³ ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona.
¹⁴ Group of Investigation in Interactions Gene-Environment and Health (GIIGAS), Institute of Biomedicine (IBIOMED), University of León, León.
¹⁵ Instituto de Investigación Sanitaria y Biomédica de Alicante, Universidad Miguel Hernandez (ISABIAL-UMH), Alicante, Spain.
¹⁶ Mexico National Institute of Public Health, Morelos.
¹⁷ Facultad de Medicina, UNAM, Coyoacán, Mexico.
¹⁸ Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York, USA.
¹⁹ Department of Public and Community Health, School of Public Health, University of West Attica.
²⁰ Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
²¹ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
²² Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, USA.
²³ Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
²⁴ Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA.
²⁵ Centro Internacional de Pesquisa, A. C. Camargo Cancer Center, São Paulo, Brazil.
²⁶ EPIUnit - Instituto de Saúde Pública da Universidade do Porto.
²⁷ Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR).
²⁸ Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.

PMID: 36912187
PMCID: PMC10073218
DOI: 10.1097/CEJ.0000000000000754

Meta-Analysis

Mushroom consumption and risk of gastric cancer: a pooled analysis within the stomach cancer pooling project and a combined meta-analysis with other observational studies

Djibril M Ba et al. Eur J Cancer Prev. 2023.

. 2023 May 1;32(3):222-228.

doi: 10.1097/CEJ.0000000000000754. Epub 2023 Mar 13.

Authors

Affiliations

¹ Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
² Department of Clinical Sciences and Community Health, University of Milan, Milan.
³ Pegaso Online University, Naples.
⁴ Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy.
⁵ Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, California, USA.
⁶ Medical Informatics Center, Peking University, Peking, China.
⁷ Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center.
⁸ National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.
⁹ Nikkei Disease Prevention Center, São Paulo, Brazil.
¹⁰ Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia.
¹¹ Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid.
¹² Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat.
¹³ ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona.
¹⁴ Group of Investigation in Interactions Gene-Environment and Health (GIIGAS), Institute of Biomedicine (IBIOMED), University of León, León.
¹⁵ Instituto de Investigación Sanitaria y Biomédica de Alicante, Universidad Miguel Hernandez (ISABIAL-UMH), Alicante, Spain.
¹⁶ Mexico National Institute of Public Health, Morelos.
¹⁷ Facultad de Medicina, UNAM, Coyoacán, Mexico.
¹⁸ Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York, USA.
¹⁹ Department of Public and Community Health, School of Public Health, University of West Attica.
²⁰ Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
²¹ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
²² Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, USA.
²³ Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
²⁴ Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA.
²⁵ Centro Internacional de Pesquisa, A. C. Camargo Cancer Center, São Paulo, Brazil.
²⁶ EPIUnit - Instituto de Saúde Pública da Universidade do Porto.
²⁷ Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR).
²⁸ Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.

PMID: 36912187
PMCID: PMC10073218
DOI: 10.1097/CEJ.0000000000000754

Abstract

Edible mushrooms have high concentrations of vitamins and minerals. They are considered 'functional foods' for their disease-prevention properties. Mushroom consumption may reduce the risk of gastric cancer, the fifth most common cancer worldwide. We investigated the association between mushroom consumption and gastric cancer risk in a pooled analysis within the Stomach Cancer Pooling (StoP) Project and in a meta-analysis that also included previously published studies. A total of 3900 gastric cancer cases and 7792 controls from 11 studies were included in the StoP analysis. Mushroom consumption was measured using food frequency questionnaires. Higher mushroom consumption was associated with a lower risk of gastric cancer [relative risk (RR) for the highest vs. lowest consumption categories, 0.82; 95% confidence interval (CI), 0.71-0.95]. The corresponding RRs were 0.59 (95% CI, 0.26-1.33) in a meta-analysis of four previously published studies and 0.77 for all studies combined (95% CI, 0.63-0.95; n = 15 studies). In geographic subgroup analysis, the pooled risk in Western Pacific countries was (RR, 0.59; 95% CI, 0.40-0.87; n = 6). The stronger effect in Asian countries may reflect high level of antioxidants in mushroom species consumed in Asia.

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Figures

**Fig 1.. Association of mushroom consumption (highest vs. lowest categories) with risk of gastric cancer.**
Blue squares and their corresponding lines are the point estimates and 95% confidence intervals for each study. Maroon diamond represented pooled effect estimate for each subgroup.

**Fig 2.. Association of mushroom consumption (highest vs. lowest categories) with risk of gastric cancer stratified by the WHO region.**
Blue squares and their corresponding lines are the point estimates and 95% confidence intervals for each study. Maroon diamond represented pooled effect estimate for each subgroup.

See this image and copyright information in PMC

References

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Mushroom consumption and risk of gastric cancer: a pooled analysis within the stomach cancer pooling project and a combined meta-analysis with other observational studies

Affiliations

Mushroom consumption and risk of gastric cancer: a pooled analysis within the stomach cancer pooling project and a combined meta-analysis with other observational studies

Authors

Affiliations

Abstract

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical