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Review
. 2023 Apr 1;31(2):89-93.
doi: 10.1097/MOO.0000000000000877. Epub 2023 Feb 7.

Modern treatment of sinonasal undifferentiated carcinoma

Wei Li Neo  1 , Ehab Y Hanna  2 , Kimberley L Kiong  1
Affiliations
Review

Modern treatment of sinonasal undifferentiated carcinoma

Wei Li Neo et al. Curr Opin Otolaryngol Head Neck Surg. .

Abstract

Purpose of review: Sinonasal undifferentiated carcinomas are rare aggressive tumours with traditionally poor outcomes. Although multimodality treatment has been recommended by most centres, the ideal treatment sequence or regimen has not been established.

Recent findings: Recent evidence suggests that induction chemotherapy may be used for chemoselection and cytoreduction prior to definitive chemoradiotherapy. Where there is a favourable response, concurrent chemoradiotherapy is favoured, with an improved overall survival and improved rates of organ preservation.

Summary: Induction chemotherapy may be a useful guide for selection of patients for chemoradiotherapy or surgery and has shown encouraging results. Further research is required to establish the ideal induction chemotherapy regimen for this rare group of tumours.

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References

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    1. Amit M, Abdelmeguid AS, Watcheporn T, et al. Induction chemotherapy response as a guide for treatment optimization in sinonasal undifferentiated carcinoma. J Clin Oncol 2019; 37:504–512.
    1. Chambers KJ, Lehmann AE, Remenschneider A, et al. Incidence and survival patterns of sinonasal undifferentiated carcinoma in the United States. J Neurol Surg B Skull Base 2015; 76:94–100.
    1. Workman AD, Brody RM, Kuan EC, et al. Sinonasal undifferentiated carcinoma: a 15-year single institution experience. J Neurol Surg B Skull Base 2019; 80:88–95.
    1. Gamez ME, Lal D, Halyard MY, et al. Outcomes and patterns of failure for sinonasal undifferentiated carcinoma (SNUC): the Mayo Clinic Experience. Head Neck 2017; 39:1819–1824.

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