Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Apr 1;35(2):154-159.
doi: 10.1097/GCO.0000000000000843. Epub 2023 Jan 12.

Counseling on hormone replacement therapy: the real risks and benefits

Affiliations
Review

Counseling on hormone replacement therapy: the real risks and benefits

Amy J Voedisch. Curr Opin Obstet Gynecol. .

Abstract

Purpose of review: The menopause transition can be a time of great upheaval and suffering for some patients. Hormone replacement therapy (HRT) can relieve symptoms and improve quality of life but the perceived risks of HRT have decreased use over the past two decades. Understanding the real risks and benefits will ease physician and other healthcare professionals discomfort with counseling and prescribing this potentially life changing therapy in appropriate patients.

Recent findings: Menopausal symptoms may persist several years beyond the final menstrual period. Previously stated risks of HRT overestimated the concern with menopausal therapy. New data indicates there are medical benefits to HRT beyond quality of life measures.

Summary: In appropriate patients, the benefits of hormone replacement therapy outweigh the risks. Extended use of hormone replacement therapy is reasonable in patients with persistent symptoms.

PubMed Disclaimer

Similar articles

Cited by

  • Estrogen: the forgotten player in metaflammation.
    Zhu BT, Liao QQ, Tian HY, Yu DJ, Xie T, Sun XL, Zhou XM, Han YX, Zhao YJ, El-Kassas M, Liu XX, Sun XD, Zhang YY. Zhu BT, et al. Front Pharmacol. 2024 Nov 7;15:1478819. doi: 10.3389/fphar.2024.1478819. eCollection 2024. Front Pharmacol. 2024. PMID: 39575382 Free PMC article. Review.

References

    1. Stefanick ML. Estrogens and progestins: background and history, trends in use, and guidelines and regimens approved by the US Food and Drug Administration. Am J Med 2005; 118: (Suppl 12B): 64–73.
    1. Woodruff JD, Pickar JH. Incidence of endometrial hyperplasia in postmenopausal women taking conjugated estrogens (Premarin) with medroxyprogesterone acetate or conjugated estrogens alone. Am J Obstet Gynecol 1994; 170:1213–1223.
    1. Osteoporosis. National Institutes of Health Consensus Development Conference Statement. Natl Inst Health Consens Dev Conf Consens Statement. 1984;5(3):6.
    1. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA 2002; 288:321–333.
    1. Paciuc J. Hormone therapy in menopause. Adv Exp Med Biol 2020; 1242:89–120.