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. 2023 Mar 1;109(3):401-411.
doi: 10.1097/JS9.0000000000000170.

Efficacy of surgical treatment for post-prostatectomy urinary incontinence: a systematic review and network meta-analysis

Jae Joon Park  1 , Yejoon Hong  1 , Allison Kwon  2 , Sung Ryul Shim  3   4 , Jae Heon Kim  1
Affiliations

Efficacy of surgical treatment for post-prostatectomy urinary incontinence: a systematic review and network meta-analysis

Jae Joon Park et al. Int J Surg. .

Abstract

Objectives: Post-prostatectomy urinary incontinence (PPUI) is a major complication that reduces the quality of life in patients undergoing prostatectomy for benign prostatic hyperplasia and prostate cancer. However, there are currently limited guidelines on which surgical techniques are preferred after conservative treatment for PPUI. In this study, a systematic review and network meta-analysis (NMA) that can help determine the priority for the selection of surgical methods were performed.

Materials and methods: We retrieved data from electronic literature searches of PubMed and the Cochrane Library through August 2021. We searched for randomized controlled trials studies on the surgical treatment of PPUI after surgery for benign prostatic hyperplasia or prostate cancer and included the terms artificial urethral sphincter (AUS), adjustable sling, nonadjustable sling, and injection of the bulking agent.The NMA pooled the odds ratios and 95% credible intervals (CrIs) using the number of patients achieving urinary continence, weight of pads used per day, number of pads used per day, and the International Consultation on Incontinence Questionnaire score. The therapeutic effect of each intervention on PPUI was compared and ranked using the surface under the cumulative ranking curve.

Results: A final 11 studies, including 1116 participants, were included in our NMA. The pooled overall odds ratios of patients achieving urinary continence compared with no treatment was 3.31 (95% CrI: 0.749, 15.710) in AUS, 2.97 (95% CrI: 0.412, 16.000) in adjustable sling, 2.33 (95% CrI: 0.559, 8.290) in nonadjustable sling, and 0.26 (95% CrI: 0.025, 2.500) in injection of bulking agent. In addition, this study shows the surface under the cumulative ranking curve values of ranking probabilities for each treatment performance, which indicated that AUS ranked first in terms of continence rate, International Consultation on Incontinence Questionnaire, pad weight, and pad use count.

Conclusion: The results of this study suggested that only AUS had a statistically significant effect compared to the nontreatment group and the highest PPUI treatment effect ranking among other surgical treatments.

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Conflict of interest statement

None of the authors have potential conflicts of interest to declare in relation to the manuscript.

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

Figures

Figure 1
Figure 1
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram of the study identification and selection process.
Figure 2
Figure 2
Network plot (continence rate). AUS, artificial urethral sphincter.
Figure 3
Figure 3
RoB 2 traffic light plot.
Figure 4
Figure 4
Forest plot: (A) continence rate, (B) International Consultation on Incontinence Questionnaire, (C) pad weight, and (D) pad count. AUS, artificial urethral sphincter; CrI, credible interval.
Figure 5
Figure 5
Surface under the cumulative ranking curve plot: (A) continence rate, (B) International Consultation on Incontinence Questionnaire, (C) pad weight, and (D) pad count. AUS, artificial urethral sphincter; NMA, network meta-analysis.
See this image and copyright information in PMC

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