Trials on oxygen targets in the critically ill patients: do they change our knowledge and practice?

doi:10.1007/s00134-023-06999-9

. 2023 May;49(5):559-562.

doi: 10.1007/s00134-023-06999-9. Epub 2023 Mar 13.

Trials on oxygen targets in the critically ill patients: do they change our knowledge and practice?

Massimo Girardis¹, Angelique M E de Man², Mervyn Singer³

Affiliations

¹ Intensive Care Unit, University Hospital of Modena, Modena, Italy. girardis.massimo@unimo.it.
² Department of Intensive Care, Amsterdam University Medical Centers, location VUmc, Amsterdam, Netherlands.
³ Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.

PMID: 36912963
PMCID: PMC10010244
DOI: 10.1007/s00134-023-06999-9

Trials on oxygen targets in the critically ill patients: do they change our knowledge and practice?

Massimo Girardis et al. Intensive Care Med. 2023 May.

. 2023 May;49(5):559-562.

doi: 10.1007/s00134-023-06999-9. Epub 2023 Mar 13.

Authors

Massimo Girardis¹, Angelique M E de Man², Mervyn Singer³

Affiliations

¹ Intensive Care Unit, University Hospital of Modena, Modena, Italy. girardis.massimo@unimo.it.
² Department of Intensive Care, Amsterdam University Medical Centers, location VUmc, Amsterdam, Netherlands.
³ Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.

PMID: 36912963
PMCID: PMC10010244
DOI: 10.1007/s00134-023-06999-9

No abstract available

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Conflict of interest statement

On behalf of all authors, the corresponding author states that there is no conflict of interest.

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References

1. de Jonge E, Peelen L, Keijzers PJ, Joore H, de Lange D, van der Voort PHJ, et al. Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patients. Crit Care. 2008;12:156. doi: 10.1186/cc7150. - DOI - PMC - PubMed
1. Girardis M, Busani S, Damiani E, Donati A, Rinaldi L, Marudi A, et al. Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: the oxygen-ICU randomized clinical trial. JAMA. 2016;316:1583–1589. doi: 10.1001/jama.2016.11993. - DOI - PubMed
1. Asfar P, Schortgen F, Boisrame-Helms J, Charpentier J, Guerot E, Megarbane B, et al. Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two-by-two factorial, multicentre, randomised, clinical trial. Lancet Respir Med. 2017;5:180–190. doi: 10.1016/S2213-2600(17)30046-2. - DOI - PubMed
1. Chu DK, Kim LH, Young PJ, Zamiri N, Almenawer SA, Jaeschke R, et al. Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis. Lancet. 2018;391:1693–1705. doi: 10.1016/S0140-6736(18)30479-3. - DOI - PubMed
1. The ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Mackle D, Bellomo R, Bailey M, et al. Conservative oxygen therapy during mechanical ventilation in the ICU. N Engl J Med. 2020;382:989–998. doi: 10.1056/NEJMoa1903297. - DOI - PubMed

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[1] de Jonge E, Peelen L, Keijzers PJ, Joore H, de Lange D, van der Voort PHJ, et al. Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patients. Crit Care. 2008;12:156. doi: 10.1186/cc7150. - DOI - PMC - PubMed

[2] de Jonge E, Peelen L, Keijzers PJ, Joore H, de Lange D, van der Voort PHJ, et al. Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patients. Crit Care. 2008;12:156. doi: 10.1186/cc7150. - DOI - PMC - PubMed

[3] Girardis M, Busani S, Damiani E, Donati A, Rinaldi L, Marudi A, et al. Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: the oxygen-ICU randomized clinical trial. JAMA. 2016;316:1583–1589. doi: 10.1001/jama.2016.11993. - DOI - PubMed

[4] Girardis M, Busani S, Damiani E, Donati A, Rinaldi L, Marudi A, et al. Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: the oxygen-ICU randomized clinical trial. JAMA. 2016;316:1583–1589. doi: 10.1001/jama.2016.11993. - DOI - PubMed

[5] Asfar P, Schortgen F, Boisrame-Helms J, Charpentier J, Guerot E, Megarbane B, et al. Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two-by-two factorial, multicentre, randomised, clinical trial. Lancet Respir Med. 2017;5:180–190. doi: 10.1016/S2213-2600(17)30046-2. - DOI - PubMed

[6] Asfar P, Schortgen F, Boisrame-Helms J, Charpentier J, Guerot E, Megarbane B, et al. Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two-by-two factorial, multicentre, randomised, clinical trial. Lancet Respir Med. 2017;5:180–190. doi: 10.1016/S2213-2600(17)30046-2. - DOI - PubMed

[7] Chu DK, Kim LH, Young PJ, Zamiri N, Almenawer SA, Jaeschke R, et al. Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis. Lancet. 2018;391:1693–1705. doi: 10.1016/S0140-6736(18)30479-3. - DOI - PubMed

[8] Chu DK, Kim LH, Young PJ, Zamiri N, Almenawer SA, Jaeschke R, et al. Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis. Lancet. 2018;391:1693–1705. doi: 10.1016/S0140-6736(18)30479-3. - DOI - PubMed

[9] The ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Mackle D, Bellomo R, Bailey M, et al. Conservative oxygen therapy during mechanical ventilation in the ICU. N Engl J Med. 2020;382:989–998. doi: 10.1056/NEJMoa1903297. - DOI - PubMed

[10] The ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Mackle D, Bellomo R, Bailey M, et al. Conservative oxygen therapy during mechanical ventilation in the ICU. N Engl J Med. 2020;382:989–998. doi: 10.1056/NEJMoa1903297. - DOI - PubMed

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Trials on oxygen targets in the critically ill patients: do they change our knowledge and practice?

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Trials on oxygen targets in the critically ill patients: do they change our knowledge and practice?

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Conflict of interest statement

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