Response to: Reassessing the causal role of early life adiposity in breast cancer

Yu Hao¹, Jinyu Xiao¹, Yu Liang¹, Xueyao Wu¹, Haoyu Zhang^{2

3}, Chenghan Xiao⁴, Li Zhang¹, Stephen Burgess⁵, Nan Wang⁴, Xunying Zhao¹, Peter Kraft⁶, Jiayuan Li¹, Xia Jiang^{1

7}

Affiliations

¹ Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
² Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
³ Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
⁴ Department of Maternal, Child and Adolescent Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
⁵ MRC Biostatistics Unit, Cambridge Institute of Public Health, University of Cambridge, Cambridge, UK.
⁶ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
⁷ Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.

PMID: 36913528
PMCID: PMC10695427
DOI: 10.1093/ije/dyad028

Comment

Response to: Reassessing the causal role of early life adiposity in breast cancer

Yu Hao et al. Int J Epidemiol. 2023.

. 2023 Aug 2;52(4):1294-1295.

doi: 10.1093/ije/dyad028.

Authors

Yu Hao¹, Jinyu Xiao¹, Yu Liang¹, Xueyao Wu¹, Haoyu Zhang^{2

3}, Chenghan Xiao⁴, Li Zhang¹, Stephen Burgess⁵, Nan Wang⁴, Xunying Zhao¹, Peter Kraft⁶, Jiayuan Li¹, Xia Jiang^{1

7}

Affiliations

¹ Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
² Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
³ Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
⁴ Department of Maternal, Child and Adolescent Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
⁵ MRC Biostatistics Unit, Cambridge Institute of Public Health, University of Cambridge, Cambridge, UK.
⁶ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
⁷ Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.

PMID: 36913528
PMCID: PMC10695427
DOI: 10.1093/ije/dyad028

No abstract available

PubMed Disclaimer

Conflict of interest statement

None declared.

Comment on

Reassessing the causal role of obesity in breast cancer susceptibility: a comprehensive multivariable Mendelian randomization investigating the distribution and timing of exposure.
Hao Y, Xiao J, Liang Y, Wu X, Zhang H, Xiao C, Zhang L, Burgess S, Wang N, Zhao X, Kraft P, Li J, Jiang X. Hao Y, et al. Int J Epidemiol. 2023 Feb 8;52(1):58-70. doi: 10.1093/ije/dyac143. Int J Epidemiol. 2023. PMID: 35848946 Free PMC article.
Reassessing the causal role of early-life adiposity in breast cancer: could the apparent inverse associations be a manifestation of survival bias?
Schooling CM, Fei K, Terry MB. Schooling CM, et al. Int J Epidemiol. 2023 Aug 2;52(4):1292-1293. doi: 10.1093/ije/dyad027. Int J Epidemiol. 2023. PMID: 36913517 No abstract available.

References

1. Hao Y, Xiao J, Liang Y. et al. Reassessing the causal role of obesity in breast cancer susceptibility—a comprehensive multivariable Mendelian randomization investigating the distribution and timing of exposure. Int J Epidemiol 2022;52:58–70. - PMC - PubMed
1. Vansteelandt S, Dukes O, Martinussen T.. Survivor bias in Mendelian randomization analysis. Biostatistics 2018;19:426–43. - PubMed
1. Gkatzionis A, Burgess S.. Contextualizing selection bias in Mendelian randomization: how bad is it likely to be? Int J Epidemiol 2019;48:691–701. - PMC - PubMed
1. Southey MC, Goldgar DE, Winqvist R. et al. PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS. J Med Genet 2016;53:800–11. - PMC - PubMed
1. Cancer Research UK. Breast carcinoma in situ incidence by age. https://www.cancerresearchuk.org/health-professional/cancer-statistics/s... (7 January 2023, date last accessed).

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Response to: Reassessing the causal role of early life adiposity in breast cancer

Affiliations

Response to: Reassessing the causal role of early life adiposity in breast cancer

Authors

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Conflict of interest statement

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References

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Grants and funding

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Medical