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. 2023 Jun;35(23):e2211205.
doi: 10.1002/adma.202211205. Epub 2023 Apr 20.

Coupling Probiotics with 2D CoCuMo-LDH Nanosheets as a Tumor-Microenvironment-Responsive Platform for Precise NIR-II Photodynamic Therapy

Yu Yang  1 , Tingting Hu  1 , Yixin Bian  2 , Fanqi Meng  3 , Shilong Yu  4 , Hai Li  4 , Qinghua Zhang  3 , Lin Gu  5 , Xisheng Weng  2 , Chaoliang Tan  6   7 , Ruizheng Liang  1
Affiliations

Coupling Probiotics with 2D CoCuMo-LDH Nanosheets as a Tumor-Microenvironment-Responsive Platform for Precise NIR-II Photodynamic Therapy

Yu Yang et al. Adv Mater. 2023 Jun.

Abstract

Photodynamic therapy (PDT) has become a promising cancer treatment approach with superior advantages. However, it remains a grand challenge to develop tumor microenvironment (TME)-responsive photosensitizers (PSs) for tumor-targeting precise PDT. Herein, the coupling Lactobacillus acidophilus (LA) probiotics with 2D CoCuMo layered-double-hydroxide (LDH) nanosheets (LA&LDH) is reported as a TME-responsive platform for precise NIR-II PDT. The CoCuMo-LDH nanosheets loaded on LA can be transformed from crystalline into amorphous through etching by the LA-metabolite-enabled low pH and overexpressed glutathione. The TME-induced in situ amorphization of CoCuMo-LDH nanosheets can boost its photodynamic activity for singlet oxygen (1 O2 ) generation under 1270 nm laser irradiation with relative 1 O2 quantum yield of 1.06, which is the highest among previously reported NIR-excited PSs. In vitro and in vivo assays prove that the LA&LDH can effectively achieve complete cell apoptosis and tumor eradication under 1270 nm laser irradiation. This study proves that the probiotics can be used as a tumor-targeting platform for highly efficient precise NIR-II PDT.

Keywords: in situ activation; layered double hydroxides; photodynamic therapy; probiotics; tumor-microenvironment-responsive.

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