Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 May;28(5):491-494.
doi: 10.1111/resp.14491. Epub 2023 Mar 13.

Sputum periostin is a biomarker of type 2 inflammation but not airway dysfunction in asthma

Affiliations

Sputum periostin is a biomarker of type 2 inflammation but not airway dysfunction in asthma

Taha Al-Shaikhly et al. Respirology. 2023 May.
No abstract available

Keywords: IL-13; IL-4; IL-5; airway hyperresponsiveness; asthma; periostin; type-2.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Statement

T.A.-S. has a patent MicroRNAs as Predictors of Response to Anti-IgE Therapies in Chronic Spontaneous Urticaria pending. C.W.F., J.S.D., S.F.Z., and T.S.H report grants from the National Institute of Health during the conduct of the study. M.C.P. reports grants from National Institute of Health-NHLBI, Boeringer-Ingelheim, Astrazeneca, Boehringer-Ingelheim, Genentech, GlaxoSmithKline, Sanofi-Genzyme-Regeneron, and Teva, outside the submitted work. K.W., G.J., and C.T.J.H. are employees of Genentech. All other authors declared no conflict of interest.

References

    1. Kim H, Ellis AK, Fischer D, Noseworthy M, Olivenstein R, Chapman KR, et al. Asthma biomarkers in the age of biologics. Allergy Asthma Clin Immunol. 2017; 13: 48. - PMC - PubMed
    1. Bobolea I, Barranco P, Del Pozo V, Romero D, Sanz V, Lopez-Carrasco V, et al. Sputum periostin in patients with different severe asthma phenotypes. Allergy. 2015; 70: 540–6. - PubMed
    1. Al-Shaikhly T, Murphy RC, Parker A, Lai Y, Altman MC, Larmore M, et al. Location of eosinophils in the airway wall is critical for specific features of airway hyperresponsiveness and T2 inflammation in asthma. Eur Respir J. 2022. - PMC - PubMed
    1. Altman MC, Lai Y, Nolin JD, Long S, Chen CC, Piliponsky AM, et al. Airway epithelium-shifted mast cell infiltration regulates asthmatic inflammation via IL-33 signaling. J Clin Invest. 2019; 129: 4979–91. - PMC - PubMed
    1. Jia G, Erickson RW, Choy DF, Mosesova S, Wu LC, Solberg OD, et al. Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol. 2012; 130: 647–54.e10. - PMC - PubMed

Publication types