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Comment
. 2023 Jun;20(6):355-356.
doi: 10.1038/s41571-023-00748-z.

Precision oncology for KRASG12C-mutant colorectal cancer

Federica Di Nicolantonio  1   2 , Alberto Bardelli  3   4
Affiliations
Free article
Comment

Precision oncology for KRASG12C-mutant colorectal cancer

Federica Di Nicolantonio et al. Nat Rev Clin Oncol. 2023 Jun.
Free article
No abstract available

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Comment on

  • Adagrasib with or without Cetuximab in Colorectal Cancer with Mutated KRAS G12C.
    Yaeger R, Weiss J, Pelster MS, Spira AI, Barve M, Ou SI, Leal TA, Bekaii-Saab TS, Paweletz CP, Heavey GA, Christensen JG, Velastegui K, Kheoh T, Der-Torossian H, Klempner SJ. Yaeger R, et al. N Engl J Med. 2023 Jan 5;388(1):44-54. doi: 10.1056/NEJMoa2212419. Epub 2022 Dec 21. N Engl J Med. 2023. PMID: 36546659 Free PMC article. Clinical Trial.

References

    1. Cervantes, A. et al. Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann. Oncol. 34, 10–32 (2023). - DOI - PubMed
    1. Fakih, M. et al. Real-world study of characteristics and treatment outcomes among patients with KRAS p.G12C-mutated or other KRAS mutated metastatic colorectal cancer. Oncologist 27, 663–674 (2022). - DOI - PubMed - PMC
    1. Yaeger, R. et al. Adagrasib with or without cetuximab in colorectal cancer with mutated KRAS G12C. N. Engl. J. Med. 388, 44–54 (2023). - DOI - PubMed
    1. Fakih, M. G. et al. Sotorasib for previously treated colorectal cancers with KRASG12C mutation (CodeBreaK100): a prespecified analysis of a single-arm, phase 2 trial. Lancet Oncol. 23, 115–124 (2022). - DOI - PubMed
    1. Kopetz, S. et al. Phase II pilot study of vemurafenib in patients with metastatic BRAF-mutated colorectal cancer. J. Clin. Oncol. 33, 4032–4038 (2015). - DOI - PubMed - PMC

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