Exploring the genetic landscape of HCV-related B-cell lymphomas using whole exome sequencing

Marine Armand^#^{1

2}, Michaël Degaud^#^{1

2}, Bruno Tesson³, Cécile Laurent³, Manon Vavasseur⁴, Mélanie Parisot⁵, Bénédicte Hoareau-Coudert⁶, Danielle Canioni⁷, Jean Marie Michot^{8

9}, Frédéric Charlotte¹⁰, Véronique Meignin¹¹, Camille Laurent^{12

13}, Alexandra Traverse-Gléhen^{14

15}, Diane Damotte¹⁶, Emmanuel Bachy^{17

18}, Caroline Besson^{19

20}, Olivier Hermine^{4

21}, Frédéric Davi^{1

2}, Lucile Couronné^{22

23}

Affiliations

¹ Hematology Laboratory, Hôpital Pitié-Salpêtrière, Assistance-Publique-Hôpitaux de Paris and Sorbonne University, Paris, France.
² Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Inserm, Cell Death and Drug Resistance in Lymphoproliferative Disorders Team, F-75006, Paris, France.
³ Bioinformatics Department, LYSARC, Paris, France.
⁴ Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, INSERM UMR_S 1163, Imagine Institute, Université Paris Cité, Paris, France.
⁵ Genomics Core Facility, Institut Imagine-Structure Fédérative de Recherche Necker, INSERM U1163 et INSERM US24/CNRS UAR3633, Paris Descartes Sorbonne Paris Cité University, Paris, France.
⁶ Sorbonne-Université, INSERM, UMS-037 PASS, Cytometry Facility CyPS, Paris, France.
⁷ Department of Pathology, Hôpital Necker-Enfants Malades, Assistance-Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.
⁸ Gustave Roussy Institute, Département des Innovations Thérapeutiques et Essais Précoces, Université Paris-Saclay, Villejuif, France.
⁹ Unité mixte de recherche Inserm 1170, Université Paris-Saclay, Gustave Roussy Institute, Villejuif, France.
¹⁰ Department of Pathology, Hôpital Pitié-Salpêtrière, Assistance-Publique-Hôpitaux de Paris, Sorbonne University, Paris, France.
¹¹ Department of Pathology, Hôpital Saint-Louis, Assistance-Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.
¹² Department of Pathology, CHU de Toulouse, Institut Universitaire du Cancer, Toulouse, France.
¹³ INSERM U1037, Centre de Recherche en Cancérologie de Toulouse, Toulouse, France.
¹⁴ Université Lyon 1, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS, UMR5308, ENS Lyon, France.
¹⁵ Hospices Civils de Lyon, Institut de Pathologie Multisite, Hôpital Lyon Sud, Lyon, France.
¹⁶ Department of Pathology, Hôpitaux Universitaire Paris Centre, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.
¹⁷ Department of Hematology, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, Lyon, France.
¹⁸ INSERM U1111, Lymphoma-Immunobiology Biology (LIB) Team, International Center for Research in Infectious Diseases (CIRI), Lyon, France.
¹⁹ Department of Hematology and Oncology, Centre Hospitalier de Versailles, Le Chesnay, France.
²⁰ Université Paris-Saclay, UVSQ, Inserm, Équipe "Exposome et Hérédité", CESP, Villejuif, France.
²¹ Department of Hematology, Hôpital Necker-Enfants Malades, Assistance-Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.
²² Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, INSERM UMR_S 1163, Imagine Institute, Université Paris Cité, Paris, France. lucile.couronne@aphp.fr.
²³ Laboratory of Onco-Hematology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France. lucile.couronne@aphp.fr.

^# Contributed equally.

PMID: 36914771
DOI: 10.1038/s41375-023-01868-2

Exploring the genetic landscape of HCV-related B-cell lymphomas using whole exome sequencing

Marine Armand et al. Leukemia. 2023 Jun.

. 2023 Jun;37(6):1388-1391.

doi: 10.1038/s41375-023-01868-2. Epub 2023 Mar 13.

Authors

Affiliations

¹ Hematology Laboratory, Hôpital Pitié-Salpêtrière, Assistance-Publique-Hôpitaux de Paris and Sorbonne University, Paris, France.
² Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Inserm, Cell Death and Drug Resistance in Lymphoproliferative Disorders Team, F-75006, Paris, France.
³ Bioinformatics Department, LYSARC, Paris, France.
⁴ Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, INSERM UMR_S 1163, Imagine Institute, Université Paris Cité, Paris, France.
⁵ Genomics Core Facility, Institut Imagine-Structure Fédérative de Recherche Necker, INSERM U1163 et INSERM US24/CNRS UAR3633, Paris Descartes Sorbonne Paris Cité University, Paris, France.
⁶ Sorbonne-Université, INSERM, UMS-037 PASS, Cytometry Facility CyPS, Paris, France.
⁷ Department of Pathology, Hôpital Necker-Enfants Malades, Assistance-Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.
⁸ Gustave Roussy Institute, Département des Innovations Thérapeutiques et Essais Précoces, Université Paris-Saclay, Villejuif, France.
⁹ Unité mixte de recherche Inserm 1170, Université Paris-Saclay, Gustave Roussy Institute, Villejuif, France.
¹⁰ Department of Pathology, Hôpital Pitié-Salpêtrière, Assistance-Publique-Hôpitaux de Paris, Sorbonne University, Paris, France.
¹¹ Department of Pathology, Hôpital Saint-Louis, Assistance-Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.
¹² Department of Pathology, CHU de Toulouse, Institut Universitaire du Cancer, Toulouse, France.
¹³ INSERM U1037, Centre de Recherche en Cancérologie de Toulouse, Toulouse, France.
¹⁴ Université Lyon 1, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS, UMR5308, ENS Lyon, France.
¹⁵ Hospices Civils de Lyon, Institut de Pathologie Multisite, Hôpital Lyon Sud, Lyon, France.
¹⁶ Department of Pathology, Hôpitaux Universitaire Paris Centre, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.
¹⁷ Department of Hematology, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, Lyon, France.
¹⁸ INSERM U1111, Lymphoma-Immunobiology Biology (LIB) Team, International Center for Research in Infectious Diseases (CIRI), Lyon, France.
¹⁹ Department of Hematology and Oncology, Centre Hospitalier de Versailles, Le Chesnay, France.
²⁰ Université Paris-Saclay, UVSQ, Inserm, Équipe "Exposome et Hérédité", CESP, Villejuif, France.
²¹ Department of Hematology, Hôpital Necker-Enfants Malades, Assistance-Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.
²² Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, INSERM UMR_S 1163, Imagine Institute, Université Paris Cité, Paris, France. lucile.couronne@aphp.fr.
²³ Laboratory of Onco-Hematology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France. lucile.couronne@aphp.fr.

^# Contributed equally.

PMID: 36914771
DOI: 10.1038/s41375-023-01868-2

No abstract available

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References

1. Couronné L, Bachy E, Roulland S, Nadel B, Davi F, Armand M, et al. From hepatitis C virus infection to B-cell lymphoma. Ann Oncol. 2018;29:92–100. https://doi.org/10.1093/annonc/mdx635 . - DOI - PubMed
1. Frigeni M, Besson C, Visco C, Fontaine H, Goldaniga M, Visentini M, et al. Interferon-free compared to interferon-based antiviral regimens as first-line therapy for B-cell lymphoproliferative disorders associated with hepatitis C virus infection. Leukemia. 2020;34:1462–6. https://doi.org/10.1038/s41375-019-0687-2 . - DOI - PubMed
1. Merli M, Defrancesco I, Visco C, Besson C, Di Rocco A, Arcari A, et al. Direct-acting antivirals in relapsed or refractory hepatitis C virus-associated diffuse large B-cell lymphoma. Leuk Lymphoma. 2020;61:2122–8. https://doi.org/10.1080/10428194.2020.1755859 . - DOI - PubMed
1. Arcaini L, Rossi D, Lucioni M, Nicola M, Bruscaggin A, Fiaccadori V, et al. The NOTCH pathway is recurrently mutated in diffuse large B-cell lymphoma associated with hepatitis C virus infection. Haematologica. 2015;100:246–52. https://doi.org/10.3324/haematol.2014.116855 . - DOI - PubMed - PMC
1. Defrancesco I, Visentini M, Zibellini S, Minafò YA, Rattotti S, Ferretti VV, et al. Mutational and immunogenetic landscape of HCV-associated B-cell lymphoproliferative disorders. Am J Hematol. 2021;96:E210–4. https://doi.org/10.1002/ajh.26167 . - DOI - PubMed - PMC

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Exploring the genetic landscape of HCV-related B-cell lymphomas using whole exome sequencing

Affiliations

Exploring the genetic landscape of HCV-related B-cell lymphomas using whole exome sequencing

Authors

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LinkOut - more resources

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Medical