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. 2023 Feb 18:21:1797-1806.
doi: 10.1016/j.csbj.2023.02.030. eCollection 2023.

Behavioral characteristics in sensing mechanism of the Corti

Junyi Liang  1 , Jiakun Wang  2 , Wenjuan Yao  2 , Lei Zhou  3 , Xinsheng Huang  3
Affiliations

Behavioral characteristics in sensing mechanism of the Corti

Junyi Liang et al. Comput Struct Biotechnol J. .

Abstract

Some experiments can't be realized because the cochlea's Corti is the most delicate and complex sensory organ. In this paper, some typical and special behavioral characteristics in the process of sensation were found in medical clinic. Based on the interdisciplinary principles of medicine, physics and biology, a real numerical simulation model of Corti is established. On the basis of verifying the correctness of the model, the mechanism corresponding to these typical and special behavior characteristics in the process of sensation is explored through simulation calculation and analysis. This study provides theoretical and applied basis for people to better understand the sound sensing mechanism, and provides a numerical simulation platform for further analyzing Corti's sensing mechanism and good clinical application.

Keywords: Corti; Interdisciplinary; Numerical simulation; Sound sensing mechanism; Typical behavioral characteristics.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

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Graphical abstract
Fig. 1
Fig. 1
Mesh generation of cochlear model.
Fig. 2
Fig. 2
Mesh generation of 3D Corti model.
Fig. 3
Fig. 3
The relationship between the tone and the BM induced vibrations.
Fig. 4
Fig. 4
The movement of stereocilia and its contribution to sound amplification mechanism.
Fig. 5
Fig. 5
(a) Comparison of the calculated and experimental results, including the BM displacement amplitude of the active cochlear model and the passive cochlear model with frequency; (b) the comparison of phase calculation results.
Fig. 6
Fig. 6
Displacement response of BM with frequency under different sound pressure.
Fig. 7
Fig. 7
Velocity response of BM with frequency under different sound pressure.
Fig. 8
Fig. 8
The relationship between the velocity response of the BM and the sound pressure at the characteristic position.
Fig. 9
Fig. 9
(a) the relationship between the velocity response of the BM at the characteristic position and the sound pressure of the detection sound (f1 = 8000 Hz, f2 = 10,000 Hz) under different sound-pressure interference sound; (b) the relationship between the velocity response of the BM at the characteristic position and the sound pressure of the detection sound (f1 = 8000 Hz, f2 = 1000 Hz) under different sound-pressure interference sound.
Fig. 10
Fig. 10
(a) The relationship between the displacement response of the BM and the position at a given 500 Hz frequency and 20 dB sound-pressure; (b) The relationship between the displacement response of the BM and the position at a given 500 Hz frequency and 40 dB sound-pressure; (c) The relationship between the displacement response of the BM and the position under a given frequency of 500 Hz and 60 dB sound-pressure; (d) The relationship between the displacement response of the BM and the position under a given 500 Hz frequency and 80 dB sound-pressure.
Fig. 11
Fig. 11
(a) the velocity response of the BM at 8 mm from the bottom varies with frequency in the presence of 20 dB sound-pressure; (b) the velocity response of the BM at 8 mm from the bottom varies with frequency in the presence of 40 dB sound-pressure; (c) the velocity response of the BM at 8 mm from the bottom varies with frequency in the presence of 60 dB sound-pressure; (d) the velocity response of the BM at 8 mm from the bottom varies with frequency in the presence of 80 dB sound-pressure.
Fig. 12
Fig. 12
(a) the velocity response of the BM at a distance of 8 mm from the bottom end changes with frequency under 20 dB sound pressure; (b) the velocity response of the BM at a distance of 8 mm from the bottom end changes with frequency under 40 dB sound pressure; (c) the velocity response of the BM at a distance of 8 mm from the bottom end changes with frequency under 60 dB sound pressure; (d) the velocity response of the BM at a distance of 8 mm from the bottom end changes with frequency under 80 dB sound pressure.
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