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. 1987 Oct 6;142(1):137-40.
doi: 10.1016/0014-2999(87)90663-7.

R 56865 prevents electrical and mechanical signs of ouabain intoxication in guinea-pig papillary muscle

B Vollmer  1 , C Meuter, P A Janssen
Affiliations

R 56865 prevents electrical and mechanical signs of ouabain intoxication in guinea-pig papillary muscle

B Vollmer et al. Eur J Pharmacol. .

Abstract

The effect of the new compound R 56865 on ouabain-induced intoxication (8 X 10(-7) mol/l) was studied in guinea-pig papillary muscle. The positive inotropism induced by ouabain was not impaired by R 56865. Mechanical signs of intoxication, e.g. extrasystoles and contracture, as well as the development of spike-like action potentials could be prevented by pretreatment with R 56865 (3 X 10(-10)-10(-6) mol/l). We speculate that this new compound prevents ouabain-induced Ca overload of cardiac muscle.

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