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. 1987 Nov 3;143(1):143-7.
doi: 10.1016/0014-2999(87)90746-1.

Benzodiazepine Ro 5-4864 increases coronary flow

I L Grupp  1 , J F French, M A Matlib
Affiliations

Benzodiazepine Ro 5-4864 increases coronary flow

I L Grupp et al. Eur J Pharmacol. .

Abstract

Ro 5-4864 (chlorodiazepam) increased coronary flow in isolated retrograde perfused Langendorff rat heart preparations without affecting heart rate and left ventricular contractility (dP/dt). On the other hand Ro 5-4023 (clonazepam) produced very little effect. PK 11195 which has been shown to inhibit the binding of Ro 5-4864 to cardiac muscle did not antagonize this vasodilatory effect of Ro 5-4864 but increased coronary flow by itself. The data indicate a specific vasodilatory effect of certain benzodiazepines. The mechanism of action remains unknown.

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