Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jul;202(1):147-152.
doi: 10.1111/bjh.18749. Epub 2023 Mar 14.

Accessory spleens recapitulate the immune microenvironment of the main spleen in immune thrombocytopenia

Marco Pizzi  1 , Fabrizio Vianello  2 , Luisa Lorenzi  3 , Gianni Binotto  2 , Marta Sbaraglia  1 , Federico Scarmozzino  1 , Andrea De Crescenzo  2 , Vincenza Guzzardo  1 , Simone Zoletto  2 , Fabio d'Amore  2 , Alberto Friziero  4 , Mariella D'Adda  5 , Fabio Facchetti  3 , Angelo Paolo Dei Tos  1
Affiliations

Accessory spleens recapitulate the immune microenvironment of the main spleen in immune thrombocytopenia

Marco Pizzi et al. Br J Haematol. 2023 Jul.

Abstract

Accessory spleens (AcS) may play a relevant role in immune thrombocytopenia (ITP) and possibly contribute to ITP relapse following splenectomy. Little is known about the immune microenvironment of AcS in ITP. To address this issue, we compared the histological features of eight matched AcS and main spleen (MS) samples, obtained from adult patients with primary ITP. AcS and MS had overlapping immune architectural features and lymphoid composition, suggesting that similar immunologic events occur in AcS and MS of ITP. These findings may have implications for the potential mechanisms of AcS-mediated ITP relapse. Further studies are needed to confirm these results and to dissect spleen immunity in ITP.

Keywords: immune thrombocytopenia; microenvironment; pathophysiology; spleen; splenectomy.

PubMed Disclaimer

Comment in

References

REFERENCES

    1. Provan D, Semple JW. Recent advances in the mechanisms and treatment of immune thrombocytopenia. EBioMedicine. 2022;76:103820. https://doi.org/10.1016/j.ebiom.2022.103820
    1. Garabet L, Ghanima W, Rangberg A, Teruel-Montoya R, Martinez C, Lozano ML, et al. Circulating microRNAs in patients with immune thrombocytopenia before and after treatment with thrombopoietin-receptor agonists. Platelets. 2020;31(2):198-205. https://doi.org/10.1080/09537104.2019.1585527
    1. Neunert C, Terrell DR, Arnold DM, Buchanan G, Cines DB, Cooper N, et al. American Society of Hematology 2019 guidelines for immune thrombocytopenia. Blood Adv. 2019;3(23):3829-66. https://doi.org/10.1182/bloodadvances.2019000966
    1. Thanarajasingam G, Vaidya R, Erie A, Wolanskyj AP. Accessory splenectomy for refractory immune thrombocytopenic purpura. Am J Hematol. 2011;86(6):520-3. https://doi.org/10.1002/ajh.22011
    1. Chaturvedi S, Arnold DM, McCrae KR. Splenectomy for immune thrombocytopenia: down but not out. Blood. 2018;131(11):1172-82. https://doi.org/10.1182/blood-2017-09-742353

LinkOut - more resources