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Case Reports
. 2023 Jul;70(7):e30296.
doi: 10.1002/pbc.30296. Epub 2023 Mar 14.

Rapid symptomatic improvement in two patients with ganglioglioma after restarting BRAF inhibitor therapy

Evan Cantor  1   2 , Rachel Berkovich  3 , Pournima Navalkele  4 , Nicole M Brossier  5
Affiliations
Case Reports

Rapid symptomatic improvement in two patients with ganglioglioma after restarting BRAF inhibitor therapy

Evan Cantor et al. Pediatr Blood Cancer. 2023 Jul.
No abstract available

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST STATEMENT

The authors declare that there is no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Case 1: (A) Coronal FLAIR sequence showing medullary ganglioglioma at diagnosis. (B) Coronal FLAIR sequence, prior to discontinuing initial therapy. (C) Coronal FLAIR sequence following discontinuation of initial therapy demonstrating progression of disease. (D) Coronal FLAIR following resumption of therapy demonstrating response to therapy with decreased disease burden after re-challenge.
FIGURE 2
FIGURE 2
Case 2: (A) Axial FLAIR sequence image obtained prior to therapy showing expansile, hyperintense tumor centered in the right brachium pontis with extension into the pons and right cerebellar hemisphere. (B) Axial FLAIR sequence image showing response to therapy with decreased FLAIR signal hyperintensity and expansile change of the previously seen tumor centered in the right brachium pontis. (C) Axial FLAIR sequence image showing disease recurrence with FLAIR hyperintense tumor centered in the right brachium pontis. (D) Axial FLAIR sequence image showing response to therapy with decreased FLAIR signal hyperintensity corresponding to the previously seen recurrent tumor centered in the right brachium pontis.
See this image and copyright information in PMC

References

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