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Review
. 2023 Mar 14;205(4):115.
doi: 10.1007/s00203-023-03455-6.

Multi-drug resistant ESKAPE pathogens and the uses of plants as their antimicrobial agents

Farhana Nazira Idris  1 , Masrina Mohd Nadzir  2
Affiliations
Review

Multi-drug resistant ESKAPE pathogens and the uses of plants as their antimicrobial agents

Farhana Nazira Idris et al. Arch Microbiol. .

Abstract

Infections by ESKAPE (Enterococcus sp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) pathogens cause major concern due to their multi-drug resistance (MDR). The ESKAPE pathogens are frequently linked to greater mortality, diseases, and economic burden in healthcare worldwide. Therefore, the use of plants as a natural source of antimicrobial agents provide a solution as they are easily available and safe to use. These natural drugs can also be enhanced by incorporating silver nanoparticles and combining them with existing antibiotics. By focussing the attention on the ESKAPE organisms, the MDR issue can be addressed much better.

Keywords: Antibiotics; Antimicrobial; ESKAPE; Multi-drug resistance; Pathogen; Plant.

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Conflict of interest statement

The authors have no relevant financial or non-financial interests to disclose.

Figures

Fig. 1
Fig. 1
ESKAPE multi-drug resistance bacteria
Fig. 2
Fig. 2
Multi-drug resistance mechanism
See this image and copyright information in PMC

References

    1. Abreu AC, Coqueiro A, Sultan AR, et al. Looking to nature for a new concept in antimicrobial treatments: Isoflavonoids from Cytisus striatus as antibiotic adjuvants against MRSA. Sci Rep. 2017;7:3777. doi: 10.1038/s41598-017-03716-7. - DOI - PMC - PubMed
    1. Akter M, Rahman MM, Ullah AKMA, et al. Brassica rapa var. japonica leaf extract mediated green synthesis of crystalline silver nanoparticles and evaluation of their stability, cytotoxicity and antibacterial activity. J Inorg Organomet Polym Mater. 2018;28:1483–1493. doi: 10.1007/s10904-018-0818-7. - DOI
    1. Ammulu MA, Vinay Viswanath K, Giduturi AK, et al. Phytoassisted synthesis of magnesium oxide nanoparticles from Pterocarpus marsupium rox.b heartwood extract and its biomedical applications. J Genet Eng Biotechnol. 2021;19:21. doi: 10.1186/s43141-021-00119-0. - DOI - PMC - PubMed
    1. Baker S, Volova T, Prudnikova SV, et al. Bio-hybridization of nanobactericides with cellulose films for effective treatment against members of ESKAPE multi-drug-resistant pathogens. Appl Nanosci. 2018;8:1101–1110. doi: 10.1007/s13204-018-0717-9. - DOI
    1. Bataineh SMB, Tarazi YH, Ahmad WA. Antibacterial efficacy of some medicinal plants on multidrug resistance bacteria and their toxicity on eukaryotic cells. Appl Sci. 2021;11:8479. doi: 10.3390/app11188479. - DOI

MeSH terms