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. 2023 Mar 14;16(776):eadh4937.

doi: 10.1126/scisignal.adh4937. Epub 2023 Mar 14.

IL-6 drives hepatocyte dedifferentiation

Annalisa M VanHook¹

Affiliations

PMID: 36917641
DOI: 10.1126/scisignal.adh4937

Comment

IL-6 drives hepatocyte dedifferentiation

Annalisa M VanHook. Sci Signal. 2023.

. 2023 Mar 14;16(776):eadh4937.

doi: 10.1126/scisignal.adh4937. Epub 2023 Mar 14.

Author

Annalisa M VanHook¹

Affiliation

¹ Science Signaling, AAAS, Washington, DC 20005, USA. Email: avanhook@aaas.org.

PMID: 36917641
DOI: 10.1126/scisignal.adh4937

Abstract

Injury-induced hepatocyte reprogramming depends on a proinflammatory cytokine from Kupffer cells.

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Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers.
Li L, Cui L, Lin P, Liu Z, Bao S, Ma X, Nan H, Zhu W, Cen J, Mao Y, Ma X, Jiang L, Nie Y, Ginhoux F, Li Y, Li H, Hui L. Li L, et al. Cell Stem Cell. 2023 Mar 2;30(3):283-299.e9. doi: 10.1016/j.stem.2023.01.009. Epub 2023 Feb 13. Cell Stem Cell. 2023. PMID: 36787740

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