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Review
. 2023 Jun;94(6):497-505.
doi: 10.1007/s00104-023-01830-z. Epub 2023 Mar 14.

[Pharmacotherapy of obesity-Competition to bariatric surgery or a meaningful supplement?]

[Article in German]
Tina Mazaheri  1 , Saleem Ansari  1 , Madhavi Nallagonda  1 , Lars Kollmann  2 , Felix Nickel  3 , Florian Seyfried  4   5 , Alexander Dimitri Miras  1   6
Affiliations
Review

[Pharmacotherapy of obesity-Competition to bariatric surgery or a meaningful supplement?]

[Article in German]
Tina Mazaheri et al. Chirurgie (Heidelb). 2023 Jun.

Abstract
in English, German

Obesity is a complex chronic disease and requires a long-term multimodal approach. The current treatment algorithm for treatment of obesity mainly consists of a stepwise approach, which starts with a lifestyle intervention followed by or combined with medication treatment, whereas bariatric surgery is often reserved for the last option. This article provides an overview of the currently available conservative medicinal treatment regimens and the currently approved medications as well as medications currently undergoing approval studies with respect to the efficacy and possible side effects. Special attention is paid to the importance of combination treatment of pharmacotherapy and surgery in the sense of a multimodal treatment. The data so far show that using a multimodal approach an improvement in the long-term weight loss and metabolic benefits can be achieved for the patients.

Adipositas ist eine komplexe chronische Erkrankung, die eine langfristige multimodale Therapie erfordert. Der aktuelle Therapiealgorithmus der Adipositastherapie besteht meist aus einem Stufenkonzept beginnend mit einer Lebensstilintervention, gefolgt von oder kombiniert mit einer medikamentösen Behandlung, während die bariatrische Chirurgie häufig am Ende der Therapiekaskade steht. In diesem Übersichtsartikel möchten wir einen Überblick über die aktuell verfügbaren konservativ-medikamentöse Therapieregime geben und die aktuell zugelassenen Medikamente sowie aktuell in Zulassungsstudien befindliche Medikamente bezüglich ihres Wirkungsgrades und ihrer möglichen Nebenwirkungen vorstellen. Besonderer Fokus wird auf die Bedeutung der Kombinationstherapie von Chirurgie und Pharmakotherapie im Sinne einer multimodalen Therapie gelegt. Bisherige Daten zeigen, dass durch einen multimodalen Ansatz ein verbesserter langfristiger Gewichtsverlust und metabolischer Nutzen für die Patienten erreichbar sind.

Keywords: Combined treatment; Efficacy; Long-term weight loss; Side effects; Treatment algorithm.

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References

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