Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar 14;23(1):489.
doi: 10.1186/s12889-023-15411-6.

Muscle quality index is associated with trouble sleeping: a cross-sectional population based study

Yanwei You #  1 , Yuquan Chen #  2 , Qi Zhang  3 , Ning Yan  4 , Yi Ning  5 , Qiang Cao  6
Affiliations

Muscle quality index is associated with trouble sleeping: a cross-sectional population based study

Yanwei You et al. BMC Public Health. .

Abstract

Background: Trouble sleeping is one of the major health issues nowadays. Current evidence on the correlation between muscle quality and trouble sleeping is limited.

Methods: A cross-sectional study design was applied and participants aged from 18 to 60 years in the National Health and Nutrition Examination Survey (NHANES) 2011-2014 was used for analysis. Muscle quality index (MQI) was quantitatively calculated as handgrip strength (HGS, kg) sum/ arm and appendicular skeletal muscle mass (ASM, kg) by using the sum of the non-dominant hand and dominant hand. Sleeping data was obtained by interviews and self-reported by individuals. The main analyses utilized weighted multivariable logistic regression models according to the complex multi-stage sampling design of NHANES. Restricted cubic spline model was applied to explore the non-linear relationship between MQI and trouble sleeping. Moreover, subgroup analyses concerning sociodemographic and lifestyle factors were conducted in this study.

Results: 5143 participants were finally included in. In the fully adjusted model, an increased level of MQI was significantly associated with a lower odds ratio of trouble sleeping, with OR = 0.765, 95% CI: (0.652,0.896), p = 0.011. Restricted cubic spline showed a non-linear association between MQI and trouble sleeping. However, it seemed that the prevalence of trouble sleeping decreased with increasing MQI until it reached 2.362, after which the odds ratio of trouble sleeping reached a plateau. Subgroup analyses further confirmed that the negative association between the MQI and trouble sleeping was consistent and robust across groups.

Conclusion: Overall, this study revealed that MQI can be used as a reliable predictor in odds ratio of trouble sleeping. Maintaining a certain level of muscle mass would be beneficial to sleep health. However, this was a cross-sectional study, and causal inference between MQI and trouble sleeping was worthy of further exploration.

Keywords: Muscle quality index; National Health and Nutrition Examination Survey; Population-based study; Trouble sleeping.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The flow chart of study population selection
Fig. 2
Fig. 2
The dose-response relationship between muscle quality index and trouble sleeping. Notes: Age, sex, race, body mass index, marital status, sleep duration, education attainment, poverty income ratio, smoking status, alcohol drinking status, physical activity and sedentary behavior were adjusted in the restricted cubic spline
Fig. 3
Fig. 3
Forest plot of subgroup analysis between muscle quality index and trouble sleeping. Notes: Age, sex, race, body mass index, marital status, sleep duration, education attainment, poverty income ratio, smoking status, alcohol drinking status, physical activity and sedentary behavior were adjusted in the subgroup analysis
See this image and copyright information in PMC

References

    1. Ohayon MM. Epidemiology of Insomnia: what we know and what we still need to learn. Sleep Med Rev. 2002;6(2):97–111. doi: 10.1053/smrv.2002.0186. - DOI - PubMed
    1. National Institutes of H. National Institutes of Health State of the Science Conference Statement on Manifestations and Management of Chronic Insomnia in Adults, June 13–15, 2005. Sleep. (2005) 28(9):1049-57. Epub 2005/11/05. doi: 10.1093/sleep/28.9.1049. - PubMed
    1. Leger D, Poursain B. An International Survey of Insomnia: under-recognition and under-treatment of a Polysymptomatic Condition. Curr Med Res Opin. 2005;21(11):1785–92. doi: 10.1185/030079905X65637. - DOI - PubMed
    1. Sateia MJ. International classification of Sleep Disorders-Third Edition: highlights and modifications. Chest. 2014;146(5):1387–94. doi: 10.1378/chest.14-0970. - DOI - PubMed
    1. Tobaldini E, Costantino G, Solbiati M, Cogliati C, Kara T, Nobili L et al. Sleep, Sleep Deprivation, Autonomic Nervous System and Cardiovascular Diseases. Neurosci Biobehav Rev (2017) 74(Pt B):321-9. Epub 2016/07/12. doi: 10.1016/j.neubiorev.2016.07.004. - PubMed

LinkOut - more resources