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. 1979 Apr 27;573(1):197-200.
doi: 10.1016/0005-2760(79)90186-3.

The inhibition of stearoyl-coenzyme A desaturase by phenyllactate and phenylpyruvate

W Scott, J L Foote

The inhibition of stearoyl-coenzyme A desaturase by phenyllactate and phenylpyruvate

W Scott et al. Biochim Biophys Acta. .

Abstract

The inhibition of oleic acid from stearic acid was studied using a rat liver microsomal preparation. Phenyllactic acid and phenylpyruvic acid are partially inhibitory. The may be related to the low oleic acid to stearic acid ratios found in brains of phenylketonuric persons and experimentally phenylketonuric rats.

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