Phenotypic and Genomic Characterization of ST133 Siderophore-Encoding Extensively Drug-Resistant Enterobacter hormaechei
- PMID: 36920213
- PMCID: PMC10112160
- DOI: 10.1128/aac.01737-22
Phenotypic and Genomic Characterization of ST133 Siderophore-Encoding Extensively Drug-Resistant Enterobacter hormaechei
Abstract
We identified an ST133 extensively drug-resistant Enterobacter hormaechei, C210017, with increased virulence in the Galleria mellonella infection model. Genomic analysis suggested it carried antibiotic resistance genes blaKPC-2 and mcr-9.1, and genes iutAiucABCD and iroBCDEN encoding the virulence factor, siderophores. Comparative genomics of C210017 and the 178 ST133 E. hormaechei strains in the database suggested they all belonged to serotype O3 and most strains (77.5%) carried the IncHI2 superplasmids associated with the resistance, virulence, and adaptation of the host strain.
Keywords: Enterobacter hormaechei; ST133; blaKPC-2; extensive drug resistance; genomic characterization; hypervirulence; increased virulence; mcr-9; siderophore.
Conflict of interest statement
The authors declare no conflict of interest.
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