The clinical application of polygenic risk scores: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG)

Affiliations

¹ Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA; Harvard Medical School, Boston, MA.
² Department of Pathology & Laboratory Medicine, Medical College of Wisconsin, Milwaukee, WI.
³ Division of Cardiovascular Medicine, Department of Medicine, Stanford Medicine, Stanford, CA.
⁴ Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, School of Medicine, University of Utah Health, Salt Lake City, UT.
⁵ Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH; Genetic and Genomic Medicine, Nationwide Children's Hospital, Columbus, OH.
⁶ Department of Genetics, Yale University, New Haven, CT.
⁷ Yale School of Medicine, New Haven, CT.
⁸ American College of Medical Genetics and Genomics, Bethesda, MD.

Free article

Practice Guideline

Aya Abu-El-Haija et al. Genet Med. 2023 May.

Free article

. 2023 May;25(5):100803.

doi: 10.1016/j.gim.2023.100803. Epub 2023 Mar 15.

¹ Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA; Harvard Medical School, Boston, MA.
² Department of Pathology & Laboratory Medicine, Medical College of Wisconsin, Milwaukee, WI.
³ Division of Cardiovascular Medicine, Department of Medicine, Stanford Medicine, Stanford, CA.
⁴ Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, School of Medicine, University of Utah Health, Salt Lake City, UT.
⁵ Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH; Genetic and Genomic Medicine, Nationwide Children's Hospital, Columbus, OH.
⁶ Department of Genetics, Yale University, New Haven, CT.
⁷ Yale School of Medicine, New Haven, CT.
⁸ American College of Medical Genetics and Genomics, Bethesda, MD.

No abstract available

Keywords: Clinical applications; Limitations and challenges; Polygenic risk scores.

Conflict of interest statement

Conflict of Interest The authors declare no conflicts of interest.