STeerING PI4P for innate immune activation

Chao Qin¹, Shu Feng², Pinghui Feng³

Affiliations

¹ Section of Infection and Immunity, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA.
² Department of Diabetes & Cancer Metabolism, Beckman Research Institute, City of Hope, Duarte, CA, USA.
³ Section of Infection and Immunity, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA; Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Los Angeles, CA, USA. Electronic address: pinghuif@usc.edu.

PMID: 36921569
DOI: 10.1016/j.immuni.2023.02.012

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STeerING PI4P for innate immune activation

Chao Qin et al. Immunity. 2023.

Free article

. 2023 Mar 14;56(3):463-465.

doi: 10.1016/j.immuni.2023.02.012.

Authors

Chao Qin¹, Shu Feng², Pinghui Feng³

Affiliations

¹ Section of Infection and Immunity, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA.
² Department of Diabetes & Cancer Metabolism, Beckman Research Institute, City of Hope, Duarte, CA, USA.
³ Section of Infection and Immunity, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA; Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Los Angeles, CA, USA. Electronic address: pinghuif@usc.edu.

PMID: 36921569
DOI: 10.1016/j.immuni.2023.02.012

Abstract

STING transverses the endoplasmic reticulum (ER), Golgi, and endosomal compartments before its degradation within the lysosomes. In this issue of Immunity, Fang et al. demonstrate that the enrichment of cholesterol and sphingomyelin in the trans-Golgi network and endosomes mediated by the ARMH3-PI4KB-PI4P pathway plays a pivotal role in STING activation under cGAS-dependent and -independent conditions.

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Conflict of interest statement

Declaration of interests P.F. is a consultant for Marc J Bern & Partners LLP.

Comment on

ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING.
Fang R, Jiang Q, Jia X, Jiang Z. Fang R, et al. Immunity. 2023 Mar 14;56(3):500-515.e6. doi: 10.1016/j.immuni.2023.02.004. Immunity. 2023. PMID: 36921576

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STeerING PI4P for innate immune activation

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STeerING PI4P for innate immune activation

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