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Review
. 2023 Feb 27:14:1148834.
doi: 10.3389/fendo.2023.1148834. eCollection 2023.

Management of male erectile dysfunction: From the past to the future

Chang-Ming Wang  1 , Bao-Rui Wu  1 , Ping Xiang  1 , Jun Xiao  1 , Xue-Chun Hu  1
Affiliations
Review

Management of male erectile dysfunction: From the past to the future

Chang-Ming Wang et al. Front Endocrinol (Lausanne). .

Abstract

Erectile dysfunction is a common disease of the male reproductive system, which seriously affects the life quality of patients and their partners. At present, erectile dysfunction is considered as a social-psychological-physiological disease with complex etiology and various treatment methods. Oral PDE5I is the first-line treatment for erectile dysfunction with the advantages of high safety, good effect and non-invasiveness. But intracavernosal injection, hormonal replacement therapy, vacuum erection device, penile prosthesis implantation can also be alternative treatments for patients have organic erectile dysfunction or tolerance to PDE5I. With the rapid development of technologies, some new methods, such as low-intensity extracorporeal shock wave and stem cell injection therapy can even repair the organic damage of the corpora cavernosa. These are important directions for the treatment of male erectile dysfunction in the future. In this mini-review, we will introduce these therapies in detail.

Keywords: erectile dysfunction; hormonal replacement therapy; intracavernosal injection; low-intensity extracorporeal shock wave; penile prosthesis implantation; phosphodiesterase 5 inhibitor; stem cell injection therapy; vacuum erection device.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Summary diagram of the therapies of erectile dysfunction.
See this image and copyright information in PMC

References

    1. Salonia A, Bettocchi C, Boeri L, Capogrosso P, Carvalho J, Cilesiz NC, et al. . European Association of urology guidelines on sexual and reproductive health-2021 update: Male sexual dysfunction. Eur Urol (2021) 80(3):333–57. doi: 10.1016/j.eururo.2021.06.007 - DOI - PubMed
    1. McCabe MP, Sharlip ID, Lewis R, Atalla E, Balon R, Fisher AD, et al. . Incidence and prevalence of sexual dysfunction in women and men: A consensus statement from the fourth international consultation on sexual medicine 2015. J Sex Med (2016) 13(2):144–52. doi: 10.1016/j.jsxm.2015.12.034 - DOI - PubMed
    1. Ayta IA, McKinlay JB, Krane RJ. The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU Int (1999) 84(1):50–6. doi: 10.1046/j.1464-410x.1999.00142.x - DOI - PubMed
    1. Yafi FA, Jenkins L, Albersen M, Corona G, Isidori AM, Goldfarb S, et al. . Erectile dysfunction. Nat Rev Dis Primers (2016) 2:16003. doi: 10.1038/nrdp.2016.3 - DOI - PMC - PubMed
    1. Selvin E, Burnett AL, Platz EA. Prevalence and risk factors for erectile dysfunction in the US. Am J Med (2007) 120(2):151–7. doi: 10.1016/j.amjmed.2006.06.010 - DOI - PubMed

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