Cortical and thalamic inputs drive distinct hippocampal microcircuits to modulate synchronized activity during development

Abstract

Synchronized activity, a hallmark of hippocampal network dynamics, appears early during development. Whether extrinsic inputs drive such activity remains unknown. In this issue of Neuron, Leprince et al.¹ show that synchronized activity, while modulated by both cortical and thalamic inputs ex vivo, depends solely on cortical inputs in vivo.