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Clinical Trial
. 2023 Oct 1;117(2):333-340.
doi: 10.1016/j.ijrobp.2023.02.057. Epub 2023 Mar 15.

Final Report of NRG Oncology RTOG 0022: A Phase 1/2 Study of Conformal and Intensity Modulated Radiation for Oropharyngeal Cancer

Adam S Garden  1 , Jonathan Harris  2 , Avraham Eisbruch  3 , K S Clifford Chao  4 , William H Morrison  5 , Paul M Harari  6 , Todd Allen Swanson  7 , Christopher U Jones  8 , Sue S Yom  9 , Sharon A Spencer  10 , Rufus Scrimger  11 , George Shenouda  12 , Monica Shukla  13 , Harold Y Lau  14 , Michelle Mierzwa  15 , Pedro Torres-Saavedra  2 , Quynh Thu Le  16
Affiliations
Clinical Trial

Final Report of NRG Oncology RTOG 0022: A Phase 1/2 Study of Conformal and Intensity Modulated Radiation for Oropharyngeal Cancer

Adam S Garden et al. Int J Radiat Oncol Biol Phys. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
(A) Cumulative incidence estimates (solid line) and 95% pointwise confidence intervals (dashed lines) for locoregional failure for 67 patients analyzed in NRG/RTOG 0022. (B) Kaplan-Meier estimates (solid line) and 95% pointwise confidence intervals (dashed lines) for disease-free survival for 67 patients analyzed in NRG/RTOG 0022. (C) Kaplan-Meier estimates (solid line) and 95% pointwise confidence intervals (dashed lines) for overall survival for 67 patients analyzed in NRG/RTOG 0022.
Fig. 1.
Fig. 1.
(A) Cumulative incidence estimates (solid line) and 95% pointwise confidence intervals (dashed lines) for locoregional failure for 67 patients analyzed in NRG/RTOG 0022. (B) Kaplan-Meier estimates (solid line) and 95% pointwise confidence intervals (dashed lines) for disease-free survival for 67 patients analyzed in NRG/RTOG 0022. (C) Kaplan-Meier estimates (solid line) and 95% pointwise confidence intervals (dashed lines) for overall survival for 67 patients analyzed in NRG/RTOG 0022.
Fig. 1.
Fig. 1.
(A) Cumulative incidence estimates (solid line) and 95% pointwise confidence intervals (dashed lines) for locoregional failure for 67 patients analyzed in NRG/RTOG 0022. (B) Kaplan-Meier estimates (solid line) and 95% pointwise confidence intervals (dashed lines) for disease-free survival for 67 patients analyzed in NRG/RTOG 0022. (C) Kaplan-Meier estimates (solid line) and 95% pointwise confidence intervals (dashed lines) for overall survival for 67 patients analyzed in NRG/RTOG 0022.
Fig. 2.
Fig. 2.
Cross-sectional estimates of late toxicity rates and 95% confidence intervals for 67 patients analyzed in NRG/RTOG 0022.
See this image and copyright information in PMC

References

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    1. Eisbruch A, Dawson LA, Kim HM, et al. Conformal and intensity modulated irradiation of head and neck cancer: the potential for improved target irradiation, salivary gland function, and quality of life. Acta Otorhinolaryngol Belg 1999;53(3):271–275. - PubMed
    1. Chao KS, Deasy JO, Markman J, et al. A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results. Int J Radiat Oncol Biol Phys 2001;49(4):907–916. - PubMed
    1. Ozyigit G, Blanco AI, Thorstad WL, Deasy JO, Haughey BH, Spector GJ. Intensity-modulated radiation therapy for oropharyngeal carcinoma: impact of tumor volume.Chao. Sessions DG.Int J Radiat Oncol Biol Phys 2004;59:43–50. - PubMed
    1. Butler EB, Teh BS, Grant WH 3rd. SMART (simultaneous modulated accelerated radiation therapy) boost: A new accelerated fractionation schedule for the treatment of head and neck cancer with intensity modulated radiotherapy. Int J Radiat Oncol Biol Phys 1999;45:21–32. - PubMed

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