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Review
. 2023 Feb 28:14:1077531.
doi: 10.3389/fimmu.2023.1077531. eCollection 2023.

The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update

Noushin Lotfi  1 , Zahra Yousefi  2 , Marjan Golabi  1 , Parvin Khalilian  1 , Behrooz Ghezelbash  1 , Mina Montazeri  1 , Mohammad Hossein Shams  3 , Parnian Zolfaghari Baghbadorani  1 , Nahid Eskandari  1
Affiliations
Review

The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update

Noushin Lotfi et al. Front Immunol. .

Abstract

Cancer is caused by abnormal proliferation of cells and aberrant recognition of the immune system. According to recent studies, natural products are most likely to be effective at preventing cancer without causing any noticeable complications. Among the bioactive flavonoids found in fruits and vegetables, quercetin is known for its anti-inflammatory, antioxidant, and anticancer properties. This review aims to highlight the potential therapeutic effects of quercetin on some different types of cancers including blood, lung and prostate cancers.

Keywords: apoptosis; blood cancer; lung cancer; prostate cancer; quercetin; therapy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

Figures

Figure 1
Figure 1
Quercetin induce cell apoptosis through different ways. Quercetin induced c-cytochrome-dependent apoptosis and caspase-3. Also quercetin suppressed cell cycle in different phases and inhibited the phosphorylation of PI3K/Akt and mTOR. Co-treatment quercetin with some compounds improved the efficacy and increased apoptosis.
Figure 2
Figure 2
Quercetin had anti-tumor and anti-inflammatory effects. Quercetin declined inflammatory condition through decreasing VGEF-A, NO, iNOS. Also, It increased TSP-1 mRNA and protein expression to prevent angiogenesis and suppressed metastasis by reducing VEGF secretion. Vascular endothelial growth factor A (VEGF-A); Nitric oxide (NO); Inducible nitric oxide synthase (iNOS); Thrombospondin-1 (TSP-1).
See this image and copyright information in PMC

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