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Review
. 2023 Feb 28:14:1136098.
doi: 10.3389/fimmu.2023.1136098. eCollection 2023.

The role of mesenchymal stem cell-derived EVs in diabetic wound healing

Min Jiang  1 , Xupin Jiang  1 , Hongmei Li  2 , Can Zhang  1 , Ze Zhang  1 , Chao Wu  1 , Junhui Zhang  3   4 , Jiongyu Hu  4 , Jiaping Zhang  1
Affiliations
Review

The role of mesenchymal stem cell-derived EVs in diabetic wound healing

Min Jiang et al. Front Immunol. .

Abstract

Diabetic foot is one of the most common complications of diabetes, requiring repeated surgical interventions and leading to amputation. In the absence of effective drugs, new treatments need to be explored. Previous studies have found that stem cell transplantation can promote the healing of chronic diabetic wounds. However, safety issues have limited the clinical application of this technique. Recently, the performance of mesenchymal stem cells after transplantation has been increasingly attributed to their production of exocrine functional derivatives such as extracellular vesicles (EVs), cytokines, and cell-conditioned media. EVs contain a variety of cellular molecules, including RNA, DNA and proteins, which facilitate the exchange of information between cells. EVs have several advantages over parental stem cells, including a high safety profile, no immune response, fewer ethical concerns, and a reduced likelihood of embolism formation and carcinogenesis. In this paper, we summarize the current knowledge of mesenchymal stem cell-derived EVs in accelerating diabetic wound healing, as well as their potential clinic applications.

Keywords: angiogenesis; diabetes wound; exosomes; extracellular vesicles; mesenchymal stem cells.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The disorders in the repair of chronic diabetic wounds.
Figure 2
Figure 2
The mechanisms of action of the various exosomes in chronic diabetic wound repair.
See this image and copyright information in PMC

References

    1. Thum T, Fraccarollo D, Schultheiss M, Froese S, Galuppo P, Widder JD, et al. . Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes. Diabetes (2007) 56(3):666–74. doi: 10.2337/db06-0699 - DOI - PubMed
    1. Ramirez-Acuña JM, Cardenas-Cadena SA, Marquez-Salas PA, Garza-Veloz I, Perez-Favila A, Cid-Baez MA, et al. . Diabetic foot ulcers: Current advances in antimicrobial therapies and emerging treatments. Antibiot (Basel) (2019) 8(4):193. doi: 10.3390/antibiotics8040193 - DOI - PMC - PubMed
    1. Chang M, Nguyen TT. Strategy for treatment of infected diabetic foot ulcers. Acc Chem Res (2021) 54(5):1080–93. doi: 10.1021/acs.accounts.0c00864 - DOI - PubMed
    1. Volarevic V, Markovic BS, Gazdic M, Volarevic A, Jovicic N, Arsenijevic N, et al. . Ethical and safety issues of stem cell-based therapy. Int J Med Sci (2018) 15(1):36–45. doi: 10.7150/ijms.21666 - DOI - PMC - PubMed
    1. Mathieu M, Martin-Jaular L, Lavieu G, Théry C. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol (2019) 21(1):9–17. doi: 10.1038/s41556-018-0250-9 - DOI - PubMed

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