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Editorial
. 2023 Apr 15;207(8):971-972.
doi: 10.1164/rccm.202302-0284ED.

SOX17 at the Intersection of Sex, Transcription, and Metabolism in Pulmonary Hypertension

Susan M Lin  1 , David B Frank  2
Affiliations
Editorial

SOX17 at the Intersection of Sex, Transcription, and Metabolism in Pulmonary Hypertension

Susan M Lin et al. Am J Respir Crit Care Med. .
No abstract available

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Comment on

  • SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics.
    Sangam S, Sun X, Schwantes-An TH, Yegambaram M, Lu Q, Shi Y, Cook T, Fisher A, Frump AL, Coleman A, Sun Y, Liang S, Crawford H, Lutz KA, Maun AD, Pauciulo MW, Karnes JH, Chaudhary KR, Stewart DJ, Langlais PR, Jain M, Alotaibi M, Lahm T, Jin Y, Gu H, Tang H, Nichols WC, Black SM, Desai AA. Sangam S, et al. Am J Respir Crit Care Med. 2023 Apr 15;207(8):1055-1069. doi: 10.1164/rccm.202203-0450OC. Am J Respir Crit Care Med. 2023. PMID: 36913491 Free PMC article.

References

    1. Gräf S, Haimel M, Bleda M, Hadinnapola C, Southgate L, Li W, et al. Identification of rare sequence variation underlying heritable pulmonary arterial hypertension. Nat Commun . 2018;9:1416. - PMC - PubMed
    1. Yang H, Lee S, Lee S, Kim K, Yang Y, Kim JH, et al. Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice. J Clin Invest . 2013;123:418–431. - PMC - PubMed
    1. Lee SH, Lee S, Yang H, Song S, Kim K, Saunders TL, et al. Notch pathway targets proangiogenic regulator Sox17 to restrict angiogenesis. Circ Res . 2014;115:215–226. - PubMed
    1. Corada M, Orsenigo F, Morini MF, Pitulescu ME, Bhat G, Nyqvist D, et al. Sox17 is indispensable for acquisition and maintenance of arterial identity. Nat Commun . 2013;4:2609. - PMC - PubMed
    1. Liu M, Zhang L, Marsboom G, Jambusaria A, Xiong S, Toth PT, et al. Sox17 is required for endothelial regeneration following inflammation-induced vascular injury. Nat Commun . 2019;10:2126. - PMC - PubMed

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