Hypoglycemic effect of Coffea arabica leaf extracts and major bioactive constituents

G O Nascimento¹, S P D Marques², C E G Maia¹, A F de Sousa¹, R L Cunha³, M R Malta³, R W Owen¹, M K A Ferreira^{4

5}, A W da Silva^{5

6}, E L Rebouças⁶, J E S A de Menezes⁵, M M Marinho⁷, E S Marinho⁷, H S Dos Santos⁸, A S M C Saliba⁹, A P Massarioli⁹, S M Alencar⁹, A G O Sartori⁹, M T S Trevisan^{1

9}

Affiliations

¹ Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
² Departamento de Química, Instituto Federal de Educação, Ciência e Tecnologia do Ceará, Quixadá, CE, Brazil.
³ Empresa de Pesquisa Agropecuária de Minas Gerais (EPAMIG), Belo Horizonte, MG, Brazil.
⁴ Postgraduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.
⁵ Itaperi Campus, Laboratory of Natural Products Chemistry - LQPN-S, State University of Ceará, Science and Technology Center (CCT), Fortaleza, Ceará, Brazil.
⁶ Northeast Biotechnology Network, Graduate Program of Biotechnology, State University of Ceará, Fortaleza, Ceará, Brazil.
⁷ Group of Theoretical Chemistry and Electrochemistry(GQTE), State University of Ceará, Limoeiro do Norte, CE, Brazil.
⁸ Center for Exact Sciences and Technology, Vale do Acarau State University, Sobral, CE, Brazil.
⁹ Luiz de Queiroz College of Agriculture, Piracicaba, SP, Brazil.

PMID: 36927332
DOI: 10.1080/07391102.2023.2188421

Hypoglycemic effect of Coffea arabica leaf extracts and major bioactive constituents

G O Nascimento et al. J Biomol Struct Dyn. 2023.

. 2023;41(24):14871-14886.

doi: 10.1080/07391102.2023.2188421. Epub 2023 Mar 16.

Authors

Affiliations

¹ Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
² Departamento de Química, Instituto Federal de Educação, Ciência e Tecnologia do Ceará, Quixadá, CE, Brazil.
³ Empresa de Pesquisa Agropecuária de Minas Gerais (EPAMIG), Belo Horizonte, MG, Brazil.
⁴ Postgraduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.
⁵ Itaperi Campus, Laboratory of Natural Products Chemistry - LQPN-S, State University of Ceará, Science and Technology Center (CCT), Fortaleza, Ceará, Brazil.
⁶ Northeast Biotechnology Network, Graduate Program of Biotechnology, State University of Ceará, Fortaleza, Ceará, Brazil.
⁷ Group of Theoretical Chemistry and Electrochemistry(GQTE), State University of Ceará, Limoeiro do Norte, CE, Brazil.
⁸ Center for Exact Sciences and Technology, Vale do Acarau State University, Sobral, CE, Brazil.
⁹ Luiz de Queiroz College of Agriculture, Piracicaba, SP, Brazil.

PMID: 36927332
DOI: 10.1080/07391102.2023.2188421

Abstract

The present study focused on investigating the antioxidant, antiglycation activity, digestive enzymes inhibition, bioaccessibility and hypoglycemic effect of C. arabica leaves extracts. The extracts deactivated the O₂•^-, ROO•, H₂O₂, HOCl reactive oxygen species. Coffee leaves showed strong inhibition of α-glucosidase (IC₅₀ = 40.30 μg mL^-1) greater than the isolated metabolites and acarbose. There was also inhibition of pancreatic lipase (IC₅₀ = 56.43 μg mL^-1) in addition to a hypoglycemic effect in zebrafish similar to acarbose and metformin. With the exception of rutin, all biocompounds were detected at all stages of in vitro digestion. Finally, these results suggest that C. arabica leaf extracts possess antidiabetic and anti-obesity properties that can be attributed to the main metabolites and the synergistic action between them.Communicated by Ramaswamy H. Sarma.

Keywords: antioxidant; pancreatic lipase; polyphenolics; zebrafish; α-glucosidase.

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Hypoglycemic effect of Coffea arabica leaf extracts and major bioactive constituents

Affiliations

Hypoglycemic effect of Coffea arabica leaf extracts and major bioactive constituents

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Substances