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Review
. 2023 Jul;20(7):475-494.
doi: 10.1038/s41569-023-00847-5. Epub 2023 Mar 16.

Obesity and the risk of cardiometabolic diseases

Pedro L Valenzuela  1   2 , Pedro Carrera-Bastos  3   4 , Adrián Castillo-García  5 , Daniel E Lieberman  6 , Alejandro Santos-Lozano  7   8 , Alejandro Lucia  9   10
Affiliations
Review

Obesity and the risk of cardiometabolic diseases

Pedro L Valenzuela et al. Nat Rev Cardiol. 2023 Jul.

Abstract

The prevalence of obesity has reached pandemic proportions, and now approximately 25% of adults in Westernized countries have obesity. Recognized as a major health concern, obesity is associated with multiple comorbidities, particularly cardiometabolic disorders. In this Review, we present obesity as an evolutionarily novel condition, summarize the epidemiological evidence on its detrimental cardiometabolic consequences and discuss the major mechanisms involved in the association between obesity and the risk of cardiometabolic diseases. We also examine the role of potential moderators of this association, with evidence for and against the so-called 'metabolically healthy obesity phenotype', the 'fatness but fitness' paradox or the 'obesity paradox'. Although maintenance of optimal cardiometabolic status should be a primary goal in individuals with obesity, losing body weight and, particularly, excess visceral adiposity seems to be necessary to minimize the risk of cardiometabolic diseases.

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References

    1. NCD Risk Factor Collaboration Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants. Lancet 387, 1377–1396 (2016). - DOI
    1. GBD 2015 Obesity Collaborators. Health effects of overweight and obesity in 195 countries over 25 years. N. Engl. J. Med. 377, 13–27 (2017). - DOI
    1. Hales, C. M., Carroll, M. D., Fryar, C. D. & Ogden, C. L. NCHS Data Brief No. 360: Prevalence of obesity and severe obesity among adults: United States, 2017–2018 https://www.cdc.gov/nchs/data/databriefs/db360-h.pdf (2020).
    1. World Health Organization. WHO European Regional Obesity Report 2022. https://apps.who.int/iris/bitstream/handle/10665/353747/9789289057738-en... (2022).
    1. Templin, T. et al. The overweight and obesity transition from the wealthy to the poor in low- and middle-income countries: a survey of household data from 103 countries. PLoS Med. 16, e1002968 (2019). - PubMed - PMC - DOI

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