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Editorial
. 2023 Apr 1;77(4):1071-1073.
doi: 10.1097/HEP.0000000000000183. Epub 2023 Feb 3.

Treatment of autoimmune hepatitis: Budesonide does not solve our problems

Silja Steinmann  1 , Ansgar W Lohse
Affiliations
Editorial

Treatment of autoimmune hepatitis: Budesonide does not solve our problems

Silja Steinmann et al. Hepatology. .
No abstract available

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Comment on

  • Budesonide as first-line treatment in patients with autoimmune hepatitis seems inferior to standard predniso(lo)ne administration.
    Díaz-González Á, Hernández-Guerra M, Pérez-Medrano I, Sapena V, Riveiro-Barciela M, Barreira-Díaz A, Gómez E, Morillas RM, Del Barrio M, Escudé L, Mateos B, Horta D, Gómez J, Conde I, Ferre-Aracil C, El Hajra I, Arencibía A, Zamora J, Fernández A, Salcedo M, Molina E, Soria A, Estévez P, López C, Álvarez-Navascúes C, García-Retortillo M, Crespo J, Londoño MC; ColHai Registry. Díaz-González Á, et al. Hepatology. 2023 Apr 1;77(4):1095-1105. doi: 10.1097/HEP.0000000000000018. Epub 2023 Jan 3. Hepatology. 2023. PMID: 36626622

References

    1. Lohse AW, Sebode M, Jørgensen MH, Ytting H, Karlsen TH, Kelly D, et al. European Reference Network on Hepatological Diseases (ERN RARE-LIVER); International Autoimmune Hepatitis Group (IAIHG). Second-line and third-line therapy for autoimmune hepatitis: a position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group. J Hepatol. 2020;73:1496–506.
    1. Mack CL, Adams D, Assis DN, Kerkar N, Manns MP, Mayo MJ, et al. Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases. Hepatology. 2020;72:671–722.
    1. European Association for the Study of the Liver. EASL Clinical Practice Guidelines: autoimmune hepatitis. J Hepatol. 2015;63:971–1004; Epub September 1, 2015. Erratum in: J Hepatol. 2015;63(6):1543–4.
    1. Edsbäcker S, Andersson T. Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn’s disease. Clin Pharmacokinet. 2004;43:803–21.
    1. Manns MP, Woynarowski M, Kreisel M, Lurie Y, Rust C, Zuckerman E, et al. Budesonide induces remission more effectively than prednisone in a controlled trial of patients with autoimmune hepatitis. Gastroenterology. 2010;139:1198–206.

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