The Who, What, When, and Where of Inpatient Direct Oral Penicillin Challenge-Implications for Health Services Implementation

Jason Anthony Trubiano^{1

2}, Sara Vogrin^{1

2}, Elise Mitri^{1

2

3}, Rebecca Hall¹, Ana Copaescu^{1

2

4}, Jamie Waldron¹, Joseph De Luca¹, Morgan Rose^{1

2

5}, Geoff Mackay⁶, Belinda Lambros⁵, Abby P Douglas^{1

5

7}, Natasha E Holmes^{1

2

8}, Kyra Y L Chua¹

Affiliations

¹ Department of Infectious Diseases, Centre for Antibiotic Allergy and Research, Austin Health, Heidelberg, Victoria, Australia.
² Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
³ Department of Pharmacy, Austin Health, Heidelberg, Victoria, Australia.
⁴ Department of Medicine, Division of Allergy and Clinical Immunology, McGill University Health Center, Montreal, Quebec, Canada.
⁵ Department of Infectious Diseases, The National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Parkville, VIC, Australia.
⁶ Albury Wodonga Health, Albury, New South Wales, Australia.
⁷ Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
⁸ Data Analytics Research and Evaluation (DARE) Centre, Austin Health and The University of Melbourne, Heidelberg, Victoria, Australia.

PMID: 36929823
DOI: 10.1093/cid/ciad156

Multicenter Study

The Who, What, When, and Where of Inpatient Direct Oral Penicillin Challenge-Implications for Health Services Implementation

Jason Anthony Trubiano et al. Clin Infect Dis. 2023.

. 2023 Jul 5;77(1):19-22.

doi: 10.1093/cid/ciad156.

Authors

Affiliations

¹ Department of Infectious Diseases, Centre for Antibiotic Allergy and Research, Austin Health, Heidelberg, Victoria, Australia.
² Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
³ Department of Pharmacy, Austin Health, Heidelberg, Victoria, Australia.
⁴ Department of Medicine, Division of Allergy and Clinical Immunology, McGill University Health Center, Montreal, Quebec, Canada.
⁵ Department of Infectious Diseases, The National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Parkville, VIC, Australia.
⁶ Albury Wodonga Health, Albury, New South Wales, Australia.
⁷ Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
⁸ Data Analytics Research and Evaluation (DARE) Centre, Austin Health and The University of Melbourne, Heidelberg, Victoria, Australia.

PMID: 36929823
DOI: 10.1093/cid/ciad156

Abstract

Inpatient direct oral challenge programs are increasingly deployed as part of antimicrobial stewardship initiatives to reduce the burden and impacts of penicillin allergy labels on antibiotic prescribing. Using data from a prospective, multicenter cohort inpatient penicillin allergy program, we identify the key targets for delabeling to aid health service implementation.

Keywords: amoxicillin allergy; antimicrobial stewardship; beta-lactam allergy; drug allergy; oral provocation.

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Conflict of interest statement

Potential conflicts of interest. A. P. D. reports lecture honoraria from Gilead Sciences, paid directly to institution and unrelated to this work. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

Comment in

Implementing Delabeling of Beta-Lactam Allergies: Getting to the "Why"?
Jones BM, Bland CM. Jones BM, et al. Clin Infect Dis. 2023 Jul 5;77(1):23-24. doi: 10.1093/cid/ciad152. Clin Infect Dis. 2023. PMID: 36928936 No abstract available.
Linking the Who, What, When, and Where of Inpatient Direct Oral Penicillin Challenge With the How of Durable Penicillin Allergy Delabeling.
Olans RN, Olans RD. Olans RN, et al. Clin Infect Dis. 2024 Jan 25;78(1):227. doi: 10.1093/cid/ciad478. Clin Infect Dis. 2024. PMID: 37585654 No abstract available.

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The Who, What, When, and Where of Inpatient Direct Oral Penicillin Challenge-Implications for Health Services Implementation

Affiliations

The Who, What, When, and Where of Inpatient Direct Oral Penicillin Challenge-Implications for Health Services Implementation

Authors

Affiliations

Abstract

Conflict of interest statement

Comment in

Publication types

MeSH terms

Substances