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. 2023 Jan-Dec;15(1):2186115.
doi: 10.1080/19490976.2023.2186115.

Functional effects of human milk oligosaccharides (HMOs)

Meltem Dinleyici  1 , Jana Barbieur  2 , Ener Cagri Dinleyici  3 , Yvan Vandenplas  2
Affiliations

Functional effects of human milk oligosaccharides (HMOs)

Meltem Dinleyici et al. Gut Microbes. 2023 Jan-Dec.

Abstract

Human milk oligosaccharides (HMOs) are the third most important solid component in human milk and act in tandem with other bioactive components. Individual HMO levels and distribution vary greatly between mothers by multiple variables, such as secretor status, race, geographic region, environmental conditions, season, maternal diet, and weight, gestational age and mode of delivery. HMOs improve the gastrointestinal barrier and also promote a bifidobacterium-rich gut microbiome, which protects against infection, strengthens the epithelial barrier, and creates immunomodulatory metabolites. HMOs fulfil a variety of physiologic functions including potential support to the immune system, brain development, and cognitive function. Supplementing infant formula with HMOs is safe and promotes a healthy development of the infant revealing benefits for microbiota composition and infection prevention. Because of limited data comparing the effect of non-human oligosaccharides to HMOs, it is not known if HMOs offer an additional clinical benefit over non-human oligosaccharides. Better knowledge of the factors influencing HMO composition and their functions will help to understand their short- and long-term benefits.

Keywords: HMO; Human milk oligosaccharide; breastfeeding; human milk; microbiota.

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Conflict of interest statement

No potential conflict of interest was reported by the authors.

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References

    1. WHO. Infant and Young Child Feeding . (2021. Available online at: https://www.who.int/news-room/fact-sheets/detail/infant-and-young-child-....
    1. Meek JY, Noble L.. Policy statement: breastfeeding and the use of human milk. Pediatrics. 2022 Jul 1;150(1):e2022057988. doi:10.1542/peds.2022-057988. - DOI - PubMed
    1. Agostoni C, Braegger C, Decsi T, Kolacek S, Koletzko B, Michaelsen KF, Mihatsch W, Moreno LA, Puntis J, Shamir R, et al. Breast-feeding: a commentary by the ESPGHAN committee on nutrition. J Pediatr Gastroenterol Nutr. 2009. Jul;49(1):112–33. doi:10.1097/MPG.0b013e31819f1e05. - DOI - PubMed
    1. Sprenger N, Tytgat HLP, Binia A, Austin S, Singhal A. Biology of human milk oligosaccharides: from basic science to clinical evidence. J Hum Nutr Diet. 2022. Apr; 35(2): 280–299. 10.1111/jhn.12990 - DOI - PMC - PubMed
    1. Moubareck CA. Human milk microbiota and oligosaccharides: a glimpse into benefits, diversity, and correlations. Nutrients. 2021. Mar 29;13(4):1123. - PMC - PubMed

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