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Comment
. 2023 Mar;27(5):2132-2142.
doi: 10.26355/eurrev_202303_31586.

COVID-19: booster(s) vs. hospitalization and Intensive Care Unit admission

O Baydar Toprak  1 , T Akpolat, O Uzun, P Pınar Deniz, N Kokturk, A Varol, E Guzel, M Ercelik, O Gultekin, R Guner, S Turan, Ş Gökbulut Bektaş, N Coskun, N Bakan, M Nuri Yakar, O Eren Kutsoylu, B Ergan, S Argun Barış, I Başyiğit, H Boyacı, F Çetinkaya, H Çolak, N Aykac, B Baran Ketencioğlu, Z Türe Yüce, S Akkaya Isık, E Serap Yılmaz, S Karaoğlanoğlu, S Berik Safci, G Ozkan, N Kose, D Kizilirmak, Y Havlucu, S Nural, F Kerget, Ö Sunal, A Yuksel, Z Bestepe Dursun, F Deveci, M Kuluozturk, O Ataoglu, M Dursun, S Keskin, M Emin Sezgin, E N Aktepe Sezgin, F Eser, L Akyildiz, M Selim Almaz, B Kayaaslan, I Hasanoğlu, M Bayrak, A Gümüş, G Sağcan, C Cuhadaroglu, H Kucuk, T Onyilmaz, B Mete, O Kilinc, B Oya Itil
Affiliations
Free article
Comment

COVID-19: booster(s) vs. hospitalization and Intensive Care Unit admission

O Baydar Toprak et al. Eur Rev Med Pharmacol Sci. 2023 Mar.
Free article

Abstract

Objective: As the pandemic continues, different vaccine protocols have been implemented to maintain the protection of vaccines and to provide protection against new variants. The aim of this study was to assess hospitalized patients' vaccination status and document the efficacy of boosters.

Patients and methods: The patients that were hospitalized due to COVID-19 were enrolled from 28 hospitals in Turkey for five months from September 2021. 5,331 confirmed COVID-19 patients from collaborating centers were randomly enrolled to understand/estimate the distribution of vaccination status in hospitalized patients and to compare the efficacy of vaccination/booster protocols.

Results: 2,779 men and 2,552 women of which 2,408 (45.2%) were admitted to Intensive Care Units participated in this study. It was found that the highest risk reduction for all age groups was found in groups that received 4 doses. Four doses of vaccination for every 3.7 people under 50 years of age, for every 5.7 people in the 50-64 age group, and for every 4.3 people over 65 years of age will prevent 1 patient from being admitted to intensive care. Regardless of the type of vaccine, it was found that the risk of ICU hospitalization decreased in those who were vaccinated compared to those who were not vaccinated. Regardless of the type of vaccine, the ICU risk was found to decrease 1.25-fold in those who received 1 or 2 doses of vaccine, 1.18-fold in those who received 3 doses, and 3.26-fold in those who received 4 doses.

Conclusions: The results suggested that the addition of a fourth dose is more effective in preventing intensive unit care even in disadvantaged groups.

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  • COVID-19: vaccination vs. hospitalization.
    Uzun O, Akpolat T, Varol A, Turan S, Bektas SG, Cetinkaya PD, Dursun M, Bakan N, Ketencioglu BB, Bayrak M, Baris SA, Guner R, Gunal O, Nural S, Deniz PP, Toprak OB, Ozkan G, Gumus A, Kerget F, Ercelik M, Ataoglu O, Yuksel A, Ates G, Kutsoylu OE, Kose N, Kizilirmak D, Keskin S, Gultekin O, Coskun N, Yilmaz ES, Uslu S, Basyigit İ, Ergan B, Deveci F, Yakar MN, Zuhur C, Sagcan G, Yuce ZT, Kuluozturk M, Sezgin ME, Sezgin ENA, Havlucu Y, Cuhadaroglu C, Kilinc O, Boyaci H, Altunay H, Akti M, Dursun ZB, Kalem AK, Isik SA, Akyildiz L, Aykac N, Almaz MS, Kokturk N, Itil O. Uzun O, et al. Infection. 2022 Jun;50(3):747-752. doi: 10.1007/s15010-021-01751-1. Epub 2022 Jan 4. Infection. 2022. PMID: 34984646 Free PMC article.