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. 2023 Mar 17;227(Suppl 1):S30-S37.
doi: 10.1093/infdis/jiac316.

The Evolution of Assessing Central Nervous System Complications in Human Immunodeficiency Virus: Where Do We Go From Here?

Roger C McIntosh  1 , Uraina S Clark  2 , Mariana Cherner  3 , Lucette A Cysique  4   5 , Robert K Heaton  3 , Jules Levin  6 , Robert H Remien  7 , April Thames  8 , David J Moore  3 , Leah H Rubin  9
Affiliations

The Evolution of Assessing Central Nervous System Complications in Human Immunodeficiency Virus: Where Do We Go From Here?

Roger C McIntosh et al. J Infect Dis. .

Abstract

In this fifth decade of the human immunodeficiency virus (HIV) epidemic, central nervous system (CNS) complications including cognitive impairment and mental health remain a burden for people with HIV (PWH) on antiretroviral therapy. Despite the persistence of these complications, which often co-occur, the underlying pathophysiology remains elusive and consequently treatments remain limited. To continue to grow our understanding of the underlying mechanisms of CNS complications among PWH, there is a need to reexamine our current approaches, which are now more than 2 decades old. At the 2021 National Institutes of Health-sponsored meeting on Biotypes of CNS Complications in PWH, the Neurobehavioral Working Group addressed the following: (1) challenges inherent to determining CNS complications; (2) heterogeneity in CNS complications; and (3) problems and solutions for examining integrated biotypes. The review below provides a summary of the main points presented and discussed by the Neurobehavioral Working Group at the meeting.

Keywords: cognitive dysfunction; comorbidity; human immunodeficiency virus; neuropsychological testing; psychosocial factors.

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